ArticleBMC pulmonary medicine2025
Airway Candida diversity in COPD patients and its differential stimulatory effects on lung inflammation in mice.
Article in BMC pulmonary medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Candida-associated immune and metabolic rewiring in chronic obstructive pulmonary disease.BMC pulmonary medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundThe airway microbiome is altered in chronic obstructive pulmonary disease (COPD) individuals with high fungal diversity, which manifests mainly as an increase in the diversity of Candida genera. Acute exacerbation of COPD (AECOPD) is a crucial process in disease progression. The airway Candida species diversity in AECOPD patients and their differential stimulatory effects on airway inflammation in mice remain unclear. AIMS AND
methodsTo investigate the diversity of airway Candida species involved in AECOPD and assess their differential effects on airway inflammation in mice. We conducted airway bacterial and fungal microbiota surveys using 16S rRNA (V4 region) sequencing, ITS1 sequencing, and fungal cultures from sputum samples of 63 AECOPD patients. Subsequently, five Candida species isolated from airways were nasally colonized into mice. He staining, qPCR and 16S rRNA V4 region sequencing of mouse lung tissues were performed to explore the host inflammatory responses to different Candida species.
resultsCandida species were detected in the sputum of 50 (80.95%) of the 63 volunteers with AECOPD. Candida albicans, Candida glabrata, Candida parapsilosis, Candida orthopsilosis, and Candida dubliniensis were the five most prevalent species. Nasal Candida colonization in mice caused varying degrees of inflammation, with H&E staining scores of 2–7. Mouse body weight decreases significantly on days 11 and 13 after exposure to Candida albicans, Candida krusei, Candida parapsilosis, or Candida tropicalis. After a Candida albicans infection, significant increases in IL-8 and IL-1β in the mouse airways were observed. The mouse lung microbiota shifted after the addition of Candida species, with Prevotella, Streptococcus, Sutterella, Ralstonia, Sphingomonas, and Bradyrhizobiaceae being the genera identified among the six groups.
conclusionThe airways of AECOPD patients exhibit a high diversity of Candida species, each triggering distinct inflammatory patterns in mouse lungs. These findings warrant investigation into species-specific mechanisms in Candida-related COPD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.