Evidence map›Paper›PMID 41152788›Full record

ArticleBMC infectious diseases2025

Epidemiology, resistance profiles, and risk factors of multidrug-resistant Klebsiella pneumoniae: experience from a low- and middle-income country.

Banan M Aiesh, Nour Mousa, Ruba Jomaa, Yousef Zouneh, Dania Abuhalima, Motaz Saifi, Ashraqat Namrouti, Adham Abutaha, Moutaz W Sweileh, Samah W Al-Jabi and 2 more

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Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Banan M AieshInfection Control Department, An-Najah National University Hospital, Nablus, 44839, Palestine.
Nour MousaDepartment of Clinical and Community Pharmacy, Faculty of Pharmacy, An-Najah National University, Nablus, 44839, Palestine.
Ruba JomaaDepartment of Clinical and Community Pharmacy, Faculty of Pharmacy, An-Najah National University, Nablus, 44839, Palestine.
Yousef ZounehDepartment of Clinical and Community Pharmacy, Faculty of Pharmacy, An-Najah National University, Nablus, 44839, Palestine.
Dania AbuhalimaDepartment of Medicine, Faculty of Medicine and Allied Medical Sciences, An-Najah National University, Nablus, 44839, Palestine.
Motaz SaifiDepartment of Medicine, Faculty of Medicine and Allied Medical Sciences, An-Najah National University, Nablus, 44839, Palestine.
Ashraqat NamroutiInternal Medicine Department, An-Najah National University Hospital, Nablus, 44839, Palestine.
Adham AbutahaDepartment of Biomedical Sciences, Faculty of Medicine and Allied Medical Sciences, An-Najah National University, Nablus, 44839, Palestine.
Moutaz W SweilehDepartment of Biomedical Sciences, Faculty of Medicine and Allied Medical Sciences, An-Najah National University, Nablus, 44839, Palestine.
Samah W Al-JabiDepartment of Clinical and Community Pharmacy, Faculty of Pharmacy, An-Najah National University, Nablus, 44839, Palestine. samahjabi@yahoo.com.
Ali SabateenInfection Control Department, An-Najah National University Hospital, Nablus, 44839, Palestine.
Sa'ed H ZyoudDepartment of Clinical and Community Pharmacy, Faculty of Pharmacy, An-Najah National University, Nablus, 44839, Palestine. saedzyoud@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundKlebsiella pneumoniae (K. pneumoniae) is an Enterobacteriaceae and is also a normal gastrointestinal flora. Antimicrobial resistance is a growing public health concern, posing substantial challenges to modern medical practice. In this context, the aim of this study was to investigate the factors contributing to multidrug-resistant (MDR) K. pneumoniae and the prevalence and antimicrobial resistance patterns of K. pneumoniae strains isolated from patients in a major tertiary care center in Palestine. This study provides insights into multidrug-resistant pathogens, which is critical given their serious public health implications.

methodsFrom January 2022 to December 2023, a large tertiary care hospital hosted a retrospective, hospital-based study. The hospital information system provided the K. pneumoniae data. Patients of all sexes and all ages who had any kind of K. pneumoniae isolated from clinical specimens met the inclusion criteria. Patients from hemodialysis centers and outpatient clinics, as well as 20 people with insufficient medical data, were not included, resulting in a final cohort of 376 patients. This study analysed the demographic, clinical, and microbiological characteristics of patients with K. pneumoniae infections.

resultsThe mean age of patients with K. pneumoniae infections was 49.9 years, with a significantly lower mean age in the MDR group (48.5 vs. 56.4 years, p = 0.004). A greater proportion of patients were female across all subgroups. Common comorbidities included cardiovascular disease (43.4%), solid malignancies (25.8%), and diabetes mellitus (29%), although only hematological malignancies were significantly different among the subgroups (p = 0.013). Central line catheterization was significantly more common among ESBL-producing and CR-K. pneumoniae cases (p = 0.007). The most common culture sources were rectal swabs for CR-K. pneumoniae (56.6%) and urine samples for ESBL-producing strains (40%, p < 0.001). High resistance rates were observed against cephalosporins and ciprofloxacin, particularly in the ESBL and CR strains. Younger age was the only significant risk factor associated with MDR K. pneumoniae, whereas sex and comorbidities were not.

conclusionThe findings of this study highlight the significant prevalence of multidrug-resistant Klebsiella pneumoniae, a pathogen responsible for various infections. These results emphasize the critical need for antimicrobial stewardship programs to evaluate and manage antibiotic usage effectively to help combat resistance. Additionally, stringent infection control measures are necessary to reduce the risk of cross-transmission. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

Anti-Bacterial AgentsDrug Resistance, Multiple, BacterialKlebsiella InfectionsKlebsiella pneumoniaeAdultAgedAged, 80 and overDeveloping CountriesFemaleHumansMaleMicrobial Sensitivity TestsMiddle AgedMiddle EastPrevalenceRetrospective StudiesAnti-Bacterial AgentsAntimicrobial resistanceK. pneumoniaeMultidrug resistancePalestineRisk factors

Identifiers

PMID41152788
PMCPMC12560528

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.