ArticleBMC women's health2025
Global, regional, and national burden and trends of endometriosis, 1990-2021: an analysis of the global burden of disease study 2021 and forecast to 2050.
Article in BMC women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Temporal and socioeconomic trends in hospital admissions for miscarriage and ectopic pregnancy in England, 2004-2024: a nationwide study.The Lancet regional health. Europe · 2026Article
- The Circadian-Light-Hygiene Hypothesis: A Potential Modulator of Fertility and Birthrate Trends.Biology · 2026Review
- Endo-MedSAM: a promptable vision foundation model adaptation for uterus segmentation on pelvic MRI in endometriosis.Frontiers in reproductive health · 2026Article
- Endometriosis: From Genes to Global Burden.International journal of molecular sciences · 2025Article
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6 authors.
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Abstract
backgroundEndometriosis is highly prevalent but remains under-researched. This study, using the latest data, aims to provide a comprehensive assessment of the burden of endometriosis on a global scale.
methodsBased on data from the Global Burden of Disease (GBD) 2021, we analyzed the disease burden of endometriosis in terms of incidence, prevalence, and disability-adjusted life years (DALYs), focusing regional distribution and associations with the Sociodemographic index (SDI), age distribution and temporal trends, and decomposition analysis.
resultsThe disease burden of endometriosis globally and across most of countries and territories was increasing from 1990 to 2021, though the age-standardized prevalence rates (ASPR), age-standardized incidence rates (ASIR) and age-standardized DALY rates (ASR-DALY) reduced. Decomposition analysis indicates that population growth was the dominant increasing factor, while disease frequency was the primary factor reducing the burden. At the SDI level, the burden of endometriosis decreased with increasing SDI. In 15-19, 20-24, 25-29, 30-34, 35-39, 40-44, 45-49, 50-54 age groups, the disease burden increased slightly from 1990 to 2021 and may continue to rise through 2050, despite declining age-specific rates of prevalence, incidence, and DALYs. The highest incidence rates were recorded in the 20-24 age group and the disease burden peaked in the 25-29 age group, highlighting its impact on women of reproductive age.
conclusionsDespite declining age-standardized rates, the global burden of endometriosis has risen due to demographic growth and is closely linked to social development. Targeted efforts -- including early detection, timely intervention, and resource investment -- are essential, particularly for younger women at highest risk.
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