ArticleBMC anesthesiology2025
Comparison of the anesthetic efficacy and recovery quality of remimazolam besylate versus sevoflurane for pediatric circumcision: a single-center, prospective, assessor-blinded, randomized controlled study protocol.
Article in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Remimazolam versus Sevoflurane for Paediatric Circumcision: A Randomised Controlled Trial Evaluating Emergence Delirium.Drug design, development and therapy · 2026Trial
- Efficacy and Safety of Ciprofol versus Propofol for Tracheal Intubation in Pediatric Patients Undergoing Laparoscopic Hernia Repair: An Assessor-Blinded Randomised Controlled Trial.Drug design, development and therapy · 2026Trial
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundAdministering anesthesia for circumcision in children involves prioritizing safety, comfort, and quality of recovery. While the effectiveness of remimazolam besylate in pediatric anesthesia requires additional confirmation, sevoflurane has been linked to complications like agitation and delirium upon recovery. This protocol describes a planned assessor-blinded randomized controlled trial to evaluate the anesthetic impacts, recovery features, and safety profiles of remimazolam compared to sevoflurane in children between the ages of 3 and 12 undergoing circumcision.
methodsThis single-center, prospective, assessor-blinded, randomized controlled trial will be conducted at the Wanzhou District Maternal and Child Health Hospital. One hundred children (aged 3-12 years, ASA I-II) scheduled for painless circumcision will be randomly allocated to receive either intravenous remimazolam besylate (Group R, n = 50) or inhaled sevoflurane (Group S, n = 50) for general anesthesia. Both groups will receive a penile root block with 1% lidocaine. Primary outcomes include time to achieve general anesthesia (MOAA/S ≤ 1) and emergence time. Secondary outcomes include anesthesia success rate, intraoperative interventions, hemodynamic changes, respiratory complications, emergence delirium (PAED scale), pain scores (FLACC), and guardian anxiety levels. Due to inherent differences in drug delivery methods, only outcome assessors and data analysts will be blinded. Exploratory subgroup analyses by age (3-6 vs. 7-12 years) will be conducted but are not powered for definitive conclusions. Statistical analysis will use SPSS version 26.0 with significance at P < 0.05. ETHICS AND DISSEMINATION: The Reproductive Ethics Committee at the Wanzhou District Maternal and Child Health Hospital has approved this protocol (Reference No. 2024-44). Consent from the legal guardians will be secured. Findings will be shared via publications in journals and presentations at academic conferences.
trial registrationThis trial has been registered with the Chinese Clinical Trial Registry (ChiCTR) (Registration number: ChiCTR2500095974; Registration date: January 15, 2025).
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