ArticleBMC pregnancy and childbirth2025
Advanced maternal age increases the risk of adverse neonatal outcomes: a comparative study in Ethiopia.
Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Gestational age, birthweight, and maternal factors associated with neonatal mortality in the United States.Frontiers in public health · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdverse neonatal outcomes (ANOs), including preterm birth, low birth weight, low Apgar scores, congenital malformations, and early neonatal death, remain a leading cause of neonatal and infant mortality worldwide. Pregnancy at advanced maternal age (> 35 years) increases the risk of ANOs, even in the absence of other socio-economic or medical risk factors. In developing countries such as Ethiopia, where neonatal mortality is high, evidence on the impact of advanced maternal age on neonatal outcomes is limited. This highlights the need for context-specific research to inform maternal and neonatal health interventions.
objectiveThis study aimed to compare adverse neonatal outcomes and associated factors among adult and advanced-aged pregnant mothers at the public hospitals of Addis Ababa City.
methodsA hospital-based comparative cross-sectional study was conducted at public hospitals in Addis Ababa from April 29 to June 30, 2024, among 707 mothers (471 adults and 236 advanced-age). Data were collected using a systematic random sampling technique and the Open Data Kit (ODK) Collect Android application. Analyses were performed with SPSS version 26.0. Independent t-tests were used to compare continuous outcome variables between groups and estimate mean differences, while binary logistic regression analyses were employed to estimate COR and AOR with a CI of 95%. A p-value < 0.05 was considered statistically significant.
resultsThe overall response rate was 98.6%. Nearly half of advanced-aged mothers (51.5%; 95% CI: 44.7-57.9) experienced at least one ANO, compared to 40.2% (95% CI: 35.7-44.6) among adult-aged mothers, yielding a proportion difference of 11.3% (95% CI: 3.5-19.1). Overall, 44.0% (95% CI: 40.2-47.6) of neonates experienced at least one ANO. Advanced maternal age was significantly associated with unfavorable neonatal outcomes [AOR = 1.51; 95% CI: 1.02-2.25]. Specifically, advanced age was linked to increased risks of preterm birth [AOR = 1.84; 95% CI: 1.18-2.85] and large for gestational age [AOR = 2.68; 95% CI: 1.31-5.49], while it was inversely associated with post-term birth [AOR = 0.25; 95% CI: 0.08-0.83].
conclusionsAdvanced maternal age was significantly associated with increased ANOs, particularly preterm birth, and large for gestational age. To mitigate these risks, there is a need for strategy development that creates awareness on the advantages of achieving the desired number of children during early adulthood, alongside strengthening risk-based antenatal care in Ethiopia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.