Evidence map›Paper›PMID 41152723›Full record

ArticleCellular & molecular biology letters2025

Circular RNA circSLC39A10 promotes prostate cancer progression by activating Wnt signaling via the miR-936/PROX1/β-catenin axis.

Kailai Chen, Xiang Pan, Shiheng Zhang, Meiqi Xu, Xi Chen, Feng Pei, Mengyuan Wu, Fanlong Meng, Bin Sun, Manjie Zhang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular & molecular biology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kailai Chen *NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, Harbin Medical University, Harbin, 150001, China.
Xiang Pan *NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, Harbin Medical University, Harbin, 150001, China.
Shiheng Zhang *Chongqing Key Laboratory of Development and Utilization of Genuine Medicinal Materials in Three Gorges Reservoir Area, Faculty of Basic Medical Sciences, Chongqing Three Gorges Medical College, Wanzhou, 404120, China.
Meiqi XuNHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, Harbin Medical University, Harbin, 150001, China.
Xi ChenNHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, Harbin Medical University, Harbin, 150001, China.
Feng PeiNHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, Harbin Medical University, Harbin, 150001, China.
Mengyuan WuNHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, Harbin Medical University, Harbin, 150001, China.
Fanlong MengNHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, Harbin Medical University, Harbin, 150001, China.
Bin SunCollege of Pharmacy, Harbin Medical University, No. 157 Bao Jian Road, Harbin, 150080, China. binsun@hrbmu.edu.cn.
Manjie ZhangCollege of Pharmacy, Harbin Medical University, No. 157 Bao Jian Road, Harbin, 150080, China. zhangmj454@nenu.edu.cn.
Yakun LuoNHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, Harbin Medical University, Harbin, 150001, China. luoyankun@hrbmu.edu.cn.ORCID http://orcid.org/0000-0002-9644-5025

Funding

Fundamental Research Funds for the Provincial Universities of Heilongjiang 2022KYYWF-0298National Key Research and Development Program of China 2022YFA1205704Natural Science Foundation of Heilongjiang Province YQ2023H015Research Fund of Chongqing Key Laboratory of Development and Utilization of Genuine Medicine in the Three Gorges Reservoir Area KFKT2022011Research Fund of the Fourth Affiliated Hospital of Harbin Medical University HYDSYRCYJ02
6 · The paper itself

Abstract

Circular RNAs (circRNAs) play a crucial role in the initiation and development of cancers. Understanding circRNAs' functions and molecular mechanisms in tumor development is expected to reveal new diagnostic indicators and therapeutic targets of prostate cancer (PCa). In our study, we identified a new circRNA hsa-circ-0057553 (circSLC39A10) in PCa from a bioinformatic microarray analysis. The levels of circSLC39A10 were observed to be markedly elevated in both prostate cancer cells and tissues. This increased expression was associated with multiple clinicopathological features, suggesting its potential as a new diagnostic indicator for PCa. CircSLC39A10 exhibited oncogenic effects on the proliferation, migration, invasion, and metastasis of prostate cancer cells both in vivo and in vitro. CircSLC39A10 was identified as a factor that promoted the malignant progression of PCa cells through the miR-936/PROX1/β-catenin pathway, ultimately leading to the activation of Wnt signaling. Overall, circSLC39A10 is an oncogenic circRNA with potential as a biomarker for PCa. The identified circSLC39A10/miR-936/PROX1/β-catenin axis shows promise as an innovative therapeutic target for PCa.

Indexed as

beta CateninHomeodomain ProteinsMicroRNAsProstatic NeoplasmsRNA, CircularTumor Suppressor ProteinsWnt Signaling PathwayAnimalsCell Line, TumorCell MovementCell ProliferationDisease ProgressionGene Expression Regulation, NeoplasticHumansMaleMicebeta CateninHomeodomain ProteinsMicroRNAsRNA, CircularTumor Suppressor ProteinscircSLC39A10MetastasismiR-936Prostate cancerPROX1Wnt/β-catenin

Identifiers

PMID41152723
PMCPMC12560504

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.