SynthesisJournal of cosmetic dermatology2025
Botulinum Toxin Type A for Preventing Facial Trauma and Hypertrophic Scars: A Meta-Analysis and Trial Sequential Analysis.
Synthesis in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Botulinum Toxin Type A for Preventing Facial Trauma and Hypertrophic Scars: A Meta-Analysis and Trial Sequential Analysis.Journal of cosmetic dermatology · 2025Pooled it
- Combination Therapy of Intense Pulsed Light and Fractional Carbon Dioxide Laser Versus Botulinum Toxin Type A in Post-thyroidectomy Scar Prevention: A Prospective, Randomized Controlled Trial.Aesthetic plastic surgery · 2026Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the effectiveness and safety of local injection of botulinum toxin type A in preventing hypertrophic scars after facial trauma and surgery using meta-analysis and sequential experimental analysis methods.
methodComputer retrieval of randomized controlled trials on the prevention of facial scars with botulinum toxin type A from PubMed, EMbase, the Cochrane Library, CNKI, China Biomedical Literature Service System, Wanfang Database, and VIP Chinese Science and Technology Journal Full text Database up to February 2025.
resultTwelve randomized controlled clinical trials were included, with a total of 644 patients; Type A botulinum toxin injection is superior to the control group in improving patient satisfaction [RR = 6.89; 95% CI (3.20, 14.85); p < 0.0001], Vancouver Scale score [RR = -1.40; 95% CI (-2.73, 0.08); p < 0.0001], visual analog score [RR = 1.41; 95% CI (0.26, 2.56); p = 0.02], scar width [RR = -0.14; 95% CI (-0.17, -0.10); p < 0.0001], and the difference is significant; The incidence of adverse events [RR = 0.38; 95% CI (0.18, 0.84); p = 0.02] and recurrence rate [RR = 0.17; 95% CI (0.04, 0.81); p < 0.03] were lower than those in the control group, and no serious adverse reactions occurred; Sensitivity analysis showed that the results were relatively robust, sequential analysis of the experiment showed that the benefits were conclusive, and Begg's and Egger's tests showed no publication bias.
conclusionType A botulinum toxin injection has a certain therapeutic effect on hypertrophic scars without significant side effects. However, the accuracy and stability of its therapeutic effect still require more high-quality research verification.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.