ArticleClinical oral investigations2025
β-tricalcium phosphate/gelatin composite scaffolds incorporated with gentamycin-loaded chitosan microspheres for periodontal regeneration in class II furcation defects in dogs.
Article in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe present study aimed to evaluate the effect of β-tricalcium phosphate/gelatin composite scaffolds incorporated with gentamycin-loaded chitosan microspheres for periodontal regeneration in Class II Furcation Defects in Dogs. MATERIALS AND
methods24 bilateral class II furcation defects, 5 mm height, and 3 mm depth, were surgically created on the buccal surface of mandibular premolars and allowed to become chronically healed in six mongrel male dogs. Dogs were randomly divided into three groups: Group I received β-tricalcium phosphate/gelatin composite scaffolds incorporated with gentamycin-loaded chitosan microspheres (CMs (GM)-β-TCP/gelatin composite scaffolds). Group II received the same scaffolds without gentamycin. Group III received open flap debridement (OFD) as a control. The animals were sacrificed at 8 weeks post-operatively for histological and histomorphometry analysis (n = 8, α = 0.05).
resultsNew regenerative tissue was significantly (P < .001) greater in both the test groups, as they showed the highest percentage of newly formed bone height, newly formed bone area, newly formed cementum, and newly formed periodontal tissues than the control. At the same time, epithelial down growth was predominant in the control group.
conclusionWithin the limitations of this study, the novel scaffolds improved periodontal regeneration and wound healing in chronic class II furcation defects. CLINICAL RELEVANCE: The Bone regeneration property of (CMs (GM)-β-TCP/gelatin composite scaffolds) is implicated in periodontal bone defect treatment and pre-implant alveolar bone regeneration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.