Evidence map›Paper›PMID 41152615›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

Induction of oxidative stress and functional impairment by Doxorubicin in rat salivary glands.

Guilherme Eduardo Rocha Silva, Ana Clara Emilio Padovezi, Renan José Barzotti, Larissa Victorino Sampaio, Rayara Nogueira de Freitas, Cristiane Furuse, Walid D Fakhouri, Rafael Rodrigues Lima, Mariza Akemi Matsumoto, Antonio Hernandes Chaves-Neto

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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Guilherme Eduardo Rocha SilvaDepartment of Basic Sciences, School of Dentistry, São Paulo State University (Unesp), Araçatuba, SP, Brazil.
Ana Clara Emilio PadoveziDepartment of Basic Sciences, School of Dentistry, São Paulo State University (Unesp), Araçatuba, SP, Brazil.
Renan José BarzottiDepartment of Basic Sciences, School of Dentistry, São Paulo State University (Unesp), Araçatuba, SP, Brazil.
Larissa Victorino SampaioDepartment of Basic Sciences, School of Dentistry, São Paulo State University (Unesp), Araçatuba, SP, Brazil.
Rayara Nogueira de FreitasDepartment of Basic Sciences, School of Dentistry, São Paulo State University (Unesp), Araçatuba, SP, Brazil.
Cristiane FuruseDepartment of Diagnostic and Surgery, School of Dentistry, São Paulo State University (Unesp), Araçatuba, SP, Brazil.
Walid D FakhouriDepartment of Diagnostic and Biomedical Sciences, Center for Craniofacial Research, School of Dentistry, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Rafael Rodrigues LimaLaboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém, PA, Brazil.
Mariza Akemi MatsumotoDepartment of Basic Sciences, School of Dentistry, São Paulo State University (Unesp), Araçatuba, SP, Brazil.
Antonio Hernandes Chaves-NetoDepartment of Basic Sciences, School of Dentistry, São Paulo State University (Unesp), Araçatuba, SP, Brazil. antonio.hernandes@unesp.br.

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001
6 · The paper itself

Abstract

This study investigated the impact of doxorubicin (Dox) on the functional, biochemical, and redox parameters of salivary glands in rats. Male Wistar rats (six weeks old and approximately 240 g) were randomly allocated into three groups (n = 12/group): Control (saline solution), Dox2.5 (2.5 mg/kg), and Dox5.0 (5.0 mg/kg, equivalent to the human therapeutic dose of 20 mg/m

Indexed as

Antibiotics, AntineoplasticDoxorubicinOxidative StressParotid GlandSalivary GlandsSubmandibular GlandAnimalsMaleOrgan SizeRatsRats, WistarSalivaAntibiotics, AntineoplasticDoxorubicinAnthracyclineDoxorubicinOxidative stressSalivaSalivary glands

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.