Evidence map›Paper›PMID 41152600›Full record

ArticleInternational journal of colorectal disease2025

Analysis of clinicopathological features and oncological outcomes of ulcerative colitis-associated colorectal cancer based on macroscopic classification.

Ayano Saito, Yuichiro Yokoyama, Motoi Uchino, Hiroki Ikeuchi, Koji Okabayashi, Shiro Oka, Daijiro Higashi, Shimpei Ogawa, Kazuhiro Watanabe, Masatsune Shibutani and 34 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of colorectal disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

44 authors.

Ayano SaitoDepartment of Surgical Oncology, The University of Tokyo, Tokyo, Japan. saitoa-psu@h.u-tokyo.ac.jp.
Yuichiro YokoyamaDepartment of Surgical Oncology, The University of Tokyo, Tokyo, Japan.
Motoi UchinoDepartment of Inflammatory Bowel Disease Surgery, Hyogo Medical University, Nishinomiya, Japan.
Hiroki IkeuchiDepartment of Inflammatory Bowel Disease Surgery, Hyogo Medical University, Nishinomiya, Japan.
Koji OkabayashiDepartment of Surgery, Keio University School of Medicine, Tokyo, Japan.
Shiro OkaDepartment of Gastroenterology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Daijiro HigashiDepartment of Surgery, Fukuoka University Chikushi Hospital, Chikushino, Japan.
Shimpei OgawaDepartment of Surgery, Division of Inflammatory Bowel Disease Surgery, Tokyo Women's Medical University, Tokyo, Japan.
Kazuhiro WatanabeDepartment of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Masatsune ShibutaniDepartment of Gastroenterological Surgery, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Yoshiki OkitaDepartment of Gastrointestinal and Pediatric Surgery, Institute of Life Sciences, Mie University Graduate School of Medicine, Tsu, Japan.
Toshifumi WakaiDivision of Digestive and General Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Yusuke MizuuchiDepartment of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Kinya OkamotoDepartment of Coloproctology, Tokyo Yamate Medical Center, Tokyo, Japan.
Kazutaka YamadaDepartment of Surgery, Coloproctology Center, Takano Hospital, Kumamoto, Japan.
Yu SatoDepartment of Surgery, Toho University Sakura Medical Center, Chiba, Japan.
Takayuki OginoDepartment of Gastroenterological Surgery, Graduate School of Medical, Osaka University, Osaka, Japan.
Hideaki KimuraInflammatory Bowel Disease Center, Yokohama City University Medical Center, Yokohama, Japan.
Kenichi TakahashiDepartment of Colorectal Surgery, Tohoku Rosai Hospital, Sendai, Japan.
Koya HidaDepartment of Surgery, Kyoto University Hospital, Kyoto, Japan.
Yusuke KinugasaDepartment of Gastrointestinal Surgery, Institute of Science Tokyo, Tokyo, Japan.
Fumio IshidaDigestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan.
Junji OkudaDepartment of General and Gastroenterological Surgery, Osaka Medical and Pharmaceutical University, Takatsuki, Japan.
Koji DaitoDepartment of Surgery, Faculty of Medicine, Kindai University, Osaka, Japan.
Takayuki YamamotoInflammatory Bowel Disease Center, Yokkaichi Hazu Medical Center, Yokkaichi, Japan.
Seiichiro YamamotoDepartment of Gastroenterological Surgery, Tokai University School of Medicine, Tokyo, Japan.
Fumikazu KoyamaDepartment of Surgery, Nara Medical University, Nara, Japan.
Tsunekazu HanaiDepartment of Surgery, School of Medicine, Fujita Health University, Aichi, Japan.
Koji KomoriDepartment of Gastroenterological Surgery, Aichi Cancer Center Hospital, Aichi, Japan.
Dai ShidaDepartment of Surgery, IMSUT Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Junya ArakakiCenter for Gastroenterology, Department of Surgery, Urasoe General Hospital, Okinawa, Japan.
Fumihiko FujitaDepartment of Surgery, Kurume University Hospital, Kurume, Japan.
Shigeki YamaguchiDepartment of Gastroenterological Surgery, Saitama Medical University International Medical Center, Saitama, Japan.
Hideki UenoDepartment of Surgery, National Defense Medical College, Tokorozawa, Japan.
Keiji MatsudaDepartment of Surgery, Teikyo University School of Medicine, Tokyo, Japan.
Atsuo MaemotoInflammatory Bowel Disease Center, Sapporo-Higashi Tokushukai Hospital, Sapporo, Japan.
Riichiro NezuDepartment of Surgery, Nishinomiya Municipal Central Hospital, Nishinomiya, Japan.
Shin SasakiDepartment of Coloproctological Surgery, Japanese Red Cross Medical Center, Tokyo, Japan.
Eiji SunamiDepartment of Surgery, Kyorin University, Tokyo, Japan.
Tatsuki NoguchiDepartment of Surgical Oncology, The University of Tokyo, Tokyo, Japan.
Kenichi SugiharaInstitute of Science Tokyo, Tokyo, Japan.
Yoichi AjiokaDepartment of Pathology, Niigata University, Niigata, Japan.
Soichiro IshiharaDepartment of Surgical Oncology, The University of Tokyo, Tokyo, Japan.
Study Group for Inflammatory Bowel Disease Associated Intestinal Cancers by the Japanese Society for Cancer of the Colon, Rectum

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeFew studies have reported the association of macroscopic classification with clinicopathological characteristics and prognosis of ulcerative colitis-associated colorectal cancer (UC-CRC), unlike sporadic CRC. In this study, we aimed to clarify the clinical significance of macroscopic classification of UC-CRC.

methodsThe cohort included 480 patients with UC-CRC with invasion beyond the muscularis propria treated at 43 Japanese institutions between 1983 and 2023. The patients were divided into six groups based on the macroscopic type (types 0-5), and clinicopathological features and prognoses were compared.

resultsAmong 480 patients, 66 (13.8%), 75 (15.6%), 116 (24.2%), 63 (13.1%), 68 (14.2%), and 92 (19.2%) had type 0-5 tumors, respectively. There were significant differences in the clinicopathological characteristics with a younger age in type 4 or 5 tumors than in type 2 tumors (p < 0.01) and a higher frequency of undifferentiated carcinomas (p < 0.01) and lymph node metastasis (p < 0.01) and more advanced depth of invasion (p < 0.01) in type 4 tumors than in type 1 or 2 tumors. Type 4 and 5 were independent risk factors for 5-year recurrence-free survival (p = 0.02; type 4 [HR: 6.35], type 5 [HR: 5.25]) and type 0, 4, and 5 for overall survival (p = 0.02; type 0 [HR: 4.51], type 4 [HR: 5.70], type 5 [HR: 4.02]).

conclusionsType 0, 4, and 5 tumors were characteristic macroscopic types of UC-CRC and correlated with worse prognosis. Therefore, endoscopic diagnosis of the macroscopic type of UC-CRC might be helpful in determining tumor aggressiveness.

Indexed as

Colitis-Associated NeoplasmsColitis, UlcerativeColorectal NeoplasmsAdultAgedDisease-Free SurvivalFemaleHumansLymphatic MetastasisMaleMiddle AgedNeoplasm InvasivenessPrognosisRisk FactorsTreatment OutcomeMacroscopic classificationPrognosisUlcerative colitisUlcerative colitis associated cancer

Identifiers

PMID41152600
PMCPMC12568850

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.