Evidence map›Paper›PMID 41152554›Full record

ArticleExperimental & molecular medicine2025

TET1 loss propels the development of hyperthyroidism by remodeling histone modifications of PAX8 promoter.

Hui Dang, Yan Liu, Ye Zhou, Mengjun Sui, Yubo Wang, Wei Qiang, Fang Sui, Yan Zhang, Hongxin Cao, Xiaoyan Wu and 2 more

Abstract read
In one paragraph

Article in Experimental & molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hui Dang *Department of Endocrinology and Metabolism, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.
Yan Liu *Department of Endocrinology and Metabolism, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.
Ye ZhouDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.
Mengjun SuiDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.
Yubo WangDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.ORCID http://orcid.org/0000-0001-8572-7142
Wei QiangDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.
Fang SuiDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.
Yan ZhangDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.
Hongxin CaoDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.
Xiaoyan WuDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China. drxiaoyanwu@163.com.
Meiju JiCenter for Translational Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China. mjji0409@163.com.
Peng HouDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China. phou@xjtu.edu.cn.ORCID http://orcid.org/0000-0001-7010-7944

Funding

National Natural Science Foundation of China (National Science Foundation of China) 81770787National Natural Science Foundation of China (National Science Foundation of China) 82273036
6 · The paper itself

Abstract

Ten eleven translocation 1 (TET1) is a 5-methylcytosine dioxygenase, and its altered DNA demethylation has been implicated in human diseases. However, its role in regulating thyroid function remains totally unknown. Here we first generated thyroid-specific Tet1 knockout combined with thyroid-specific Braf

Indexed as

Histone CodeHyperthyroidismMixed Function OxygenasesPAX8 Transcription FactorPromoter Regions, GeneticProto-Oncogene ProteinsAnimalsDisease Models, AnimalDNA-Binding ProteinsHistonesMiceMice, KnockoutMice, TransgenicThyroid GlandDNA-Binding ProteinsHistonesMixed Function OxygenasesPax8 protein, mousePAX8 Transcription FactorProto-Oncogene ProteinsTET1 protein, mouse

Identifiers

PMID41152554
PMCPMC12586522

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.