ArticleScientific reports2025
New characteristics of MiRNA and IsomiR interactions with mRNA.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The Hidden Layer of MicroRNA Regulation in Gynecologic Cancers: IsomiRs, Arm Switching, and RNA Epitranscriptomic Modifications.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Studying the interactions between microRNAs/isomiRs and mRNAs is crucial due to their fundamental roles in gene regulation and disease. Although many isomiRs have been identified, the analysis of their interactions with mRNAs remains in its early stages. In this study, we compiled available human chimeric reads, each pairing a microRNA or isomiR segment with an mRNA segment. We then identified 1747 isomiRs and over 5 million microRNA/isomiR-mRNA interactions from the complied data. We found that microRNAs with higher adenine and thymine content, and lower cytosine content, tend to have more isomiRs and target more mRNAs. Notably, 18.9% of mRNA targets were bound exclusively by isomiRs, not their microRNAs. Furthermore, isomiRs sharing the same seed sequences as their reference miRNAs may target different mRNAs from their miRNAs, suggesting functional divergence. Interestingly, 20.0% of microRNAs and 8.2% of isomiRs bind mRNAs independently of their seed regions. Among those that do utilize seed regions, 94.5% of microRNAs and 95.7% of isomiRs also engage non-seed region binding. Our findings provide new insights into the complexity of microRNA/isomiR-mRNA interactions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.