Evidence map›Paper›PMID 41152473›Full record

ArticleScientific reports2025

Tauroursodeoxycholic acid-induced increase in ectopic muscle mineralization occurs exclusively in dystrophic muscles and is independent of endoplasmic reticulum stress.

Justyna Róg, Dorota Dymkowska, Bernadeta Michalska, Olga Krupska, Krzysztof Milewski, Paweł Matryba, Artur Wolny, Monika Pawłowska, Łukasz Bożycki, Dawid Stępnik and 2 more

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Justyna RógLaboratory of Cellular Metabolism, Nencki Institute of Experimental Biology PAS, 3 Pasteur Street, 02-093, Warsaw, Poland.
Dorota DymkowskaLaboratory of Cellular Metabolism, Nencki Institute of Experimental Biology PAS, 3 Pasteur Street, 02-093, Warsaw, Poland.
Bernadeta MichalskaLaboratory of Cellular Metabolism, Nencki Institute of Experimental Biology PAS, 3 Pasteur Street, 02-093, Warsaw, Poland.
Olga KrupskaLaboratory of Cellular Metabolism, Nencki Institute of Experimental Biology PAS, 3 Pasteur Street, 02-093, Warsaw, Poland.
Krzysztof MilewskiLaboratory of Cellular Metabolism, Nencki Institute of Experimental Biology PAS, 3 Pasteur Street, 02-093, Warsaw, Poland.
Paweł MatrybaDepartment of Immunology, Medical University of Warsaw, 5 Nielubowicz Street, 02-097, Warsaw, Poland.
Artur WolnyLaboratory of Imaging Tissue Structure and Function, Nencki Institute of Experimental Biology PAS, 3 Pasteur Street, 02-093, Warsaw, Poland.
Monika PawłowskaLaboratory of Neurobiology, BRAINCITY, Nencki Institute of Experimental Biology PAS, 3 Pasteur Street, 02-093, Warsaw, Poland.
Łukasz BożyckiLaboratory of Biochemistry of Lipids, Nencki Institute of Experimental Biology PAS, 3 Pasteur Street, 02-093, Warsaw, Poland.
Dawid StępnikLaboratory of Cytometry, Nencki Institute of Experimental Biology PAS, 3 Pasteur Street, 02-093, Warsaw, Poland.
Dariusz C GóreckiSchool of Medicine, Pharmacy and Biomedical Sciences, University of Portsmouth, St Michael's Building, White Swan Road, Portsmouth, PO1 2DT, UK.
Krzysztof ZabłockiLaboratory of Cellular Metabolism, Nencki Institute of Experimental Biology PAS, 3 Pasteur Street, 02-093, Warsaw, Poland. k.zablocki@nencki.edu.pl.

Funding

COST Action "P2X receptors as a therapeutic opportunity (PRESTO) CA21130National Science Centre Poland 2018/29/B/NZ4/02440
6 · The paper itself

Abstract

Calcification of dystrophic skeletal muscles was described previously and attributed, among others, to ER-stress, elevated phosphate concentration and chronic inflammation. Tauroursodeoxycholic acid (TUDCA) is considered an artificial chaperone protecting cells against ER-stress thus could prevent an ectopic mineralisation of soft tissues. Because an enhanced ER-stress is a feature of dystrophic muscles and it promotes soft tissue mineralisation we hypothesised that TUDCA treatment should reduce mineral deposits in dystrophic skeletal muscles, and tested this concept using two mouse models of DMD. Four-week old mdx, mdx

Indexed as

Calcification, PhysiologicCalcinosisEndoplasmic Reticulum StressMuscle, SkeletalTaurochenodeoxycholic AcidAnimalsDisease Models, AnimalMiceMice, Inbred mdxTaurochenodeoxycholic Acidursodoxicoltaurine

Identifiers

PMID41152473
PMCPMC12569086

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.