Evidence map›Paper›PMID 41152461›Full record

Articlenpj metabolic health and disease2025

Deletion of cardiac fibroblast growth factor-23 beneficially impacts myocardial energy metabolism in left ventricular hypertrophy.

Nejla Latic, Arezou Lari, Na Sun, Ana Zupcic, Mhaned Oubounyt, Juliana Falivene, Achim Buck, Martin Hofer, Wenhan Chang, Wolfgang M Kuebler and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in npj metabolic health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Nejla Latic *Department of Biological Sciences and Pathobiology, University of Veterinary Medicine, Vienna, Austria.
Arezou Lari *Ludwig Boltzmann Institute of Osteology, Vienna, Austria.
Na SunResearch Unit Analytical Pathology, German Research Center for Health and Environment, Neuherberg, Germany.
Ana ZupcicDepartment of Biological Sciences and Pathobiology, University of Veterinary Medicine, Vienna, Austria.
Mhaned OubounytInstitute for Computational Systems Biology, University of Hamburg, Hamburg, Germany.
Juliana FaliveneInstitute of Physiology, Charité University Medicine, Berlin, Germany.
Achim BuckResearch Unit Analytical Pathology, German Research Center for Health and Environment, Neuherberg, Germany.
Martin HoferGenomics Core Facility, VetCore, University of Veterinary Medicine, Vienna, Austria.
Wenhan ChangSan Francisco VA Medical Center, Department of Medicine, University of California, San Francisco, CA, USA.
Wolfgang M KueblerInstitute for Computational Systems Biology, University of Hamburg, Hamburg, Germany.
Jan BaumbachInstitute of Physiology, Charité University Medicine, Berlin, Germany.
Axel K WalchInstitute for Computational Systems Biology, University of Hamburg, Hamburg, Germany.
Alexander GrabnerDepartment of Medicine, Duke University Medical Center, Durham, NC, USA.
Reinhold G ErbenDepartment of Biological Sciences and Pathobiology, University of Veterinary Medicine, Vienna, Austria. Reinhold.Erben@lbg.ac.at.

Funding

Skeletal Biology and Biomechanics (SBB) CoreP30AR075055 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Wenhan Chang · 2019 to 2026
$7.1M
UCSF Core Center for Musculoskeletal Biology and MedicineP30AR066262 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MAJUMDAR, SHARMILA · 2014 to 2018
$3.0M
Vitamin D and beta-amyloid signaling in hyperparathyroidismRF1AG075742 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHANG, WENHAN, KOH, JAMES · 2023 to 2025
$2.4M
Austrian Science Fund P26534-B13BLRD VA I01 BX005851BLRD VA IK6 BX004835Deutsche Forschungsgemeinschaft SFB/Transregio 205 S01NIAMS NIH HHS P30 AR066262NIAMS NIH HHS P30 AR075055NIA NIH HHS RF1 AG075742
6 · The paper itself

Abstract

Left ventricular hypertrophy (LVH) is associated with increased cardiac expression of fibroblast growth factor-23 (FGF23) in mice and men. To further elucidate the role of cardiac FGF23 in LVH, we specifically ablated Fgf23 in cardiomyocytes, and employed transverse aortic constriction (TAC) to induce LVH by pressure overload. LVH developed independently of cardiac FGF23, but cardiomyocyte-specific Fgf23 knock-out (Fgf23

Identifiers

PMID41152461
PMCPMC12569085

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.