ArticleScientific reports2025
International survey-based assessment of the reliability, validity, and interpretability of the TDN grade for neurosurgical adverse events.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- Smartphone-Based Monitoring of Quality of Life and Adverse Events After Neurosurgery: Prospective Cohort Study.Journal of medical Internet research · 2026Article
- Single-level anterior cervical discectomy and fusion for degenerative disc disease: a retrospective, two-center comparative analysis of stand-alone cage versus cage-plate constructs.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Article
- Adverse events in meningioma surgery classified using the therapy-disability-neurology (TDN) grading system.Journal of neuro-oncology · 2025Article
Corrections and comments
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurosurgical adverse events (AE) are frequent and may have dramatic consequences on quality of life. The lack of a standardized classification of their severity hinders evaluation and improvement of the safety of procedures. The Therapy-Disability-Neurology (TDN) grade, validated in 2021 on 6071 interventions, overcomes limitations of previous grading-systems by addressing the severity of neurologic and disabling AEs. The aim of the current study is to assess the reliability, validity and applicability of the TDN grade. We conducted an online survey involving participants with varying levels of neurosurgical expertise. Participants assessed the TDN grade for 16 case vignettes and reviewed the validity, interpretability, logicality, simplicity, and usefulness of the grading-system. The TDN grade showed substantial inter-rater (α = 0.66) and intra-rater (α = 0.79) reliability. Most participants recommended reporting its separate dimensions, which demonstrated substantial to almost perfect reliability (inter-rater: α = 0.74; intra-rater: α = 0.85). Online calculation tools significantly improved agreement and participants' scores. The TDN grade was considered fairly useful, very logical, fairly simple to use and interpret, and its separate dimensions were considered a very valid measure of the severity of AEs. Neurosurgical AEs should be systematically reported, and surveyed neurosurgeons recommend the use of the TDN grade along its separate dimensions for this purpose.
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