Evidence map›Paper›PMID 41152336›Full record

ArticleScientific reports2025

Feasibility of intratracheal tracheostomy sealing: anatomical adaptation and biocompatibility of a second-generation prototype in cadaveric and porcine models.

Rasmus Ellerup Kraghede, Louise Winding Nielsen, Karen Juelsgaard Christiansen, Stig Dyrskog, Alexander Emil Kaspersen, Esben Beier Gynning, Jens Toft Væsel, Michael Pedersen, J Michael Hasenkam

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rasmus Ellerup KraghedeDepartment of Intensive Care, Aarhus University Hospital, Aarhus, Denmark. rakrag@clin.au.dk.
Louise Winding NielsenDepartment of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark.
Karen Juelsgaard ChristiansenDepartment of Intensive Care, Aarhus University Hospital, Aarhus, Denmark.
Stig DyrskogDepartment of Intensive Care, Aarhus University Hospital, Aarhus, Denmark.
Alexander Emil KaspersenDepartment of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark.
Esben Beier GynningDepartment of Intensive Care, Aarhus University Hospital, Aarhus, Denmark.
Jens Toft VæselDepartment of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark.
Michael PedersenDepartment of Clinical Medicine, Faculty of Health, Aarhus University, Palle Juul-Jensens Boulevard 69 - F303, 8200, Aarhus, Denmark.
J Michael HasenkamDepartment of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark.

Funding

Købmand Herman Sallings Fond 2022-0081Novo Nordisk Fonden NNF21OC0072604
6 · The paper itself

Abstract

After decannulation, air leak through the tracheostoma can impair cough and voice. We evaluated a second-generation temporary intratracheal sealing disc that seals the stoma from within. Two preclinical sub-studies were performed: Sub-study 1 cadaveric deployment to assess anatomical fit, seal integrity, and removability; and Sub-study 2, a 7-day porcine implantation with anatomical compatibility and blinded histology. In cadavers, the sealing disc maintained airway patency and sealed the stoma, withstanding peak intratracheal pressures up to 180 cmH

Indexed as

Biocompatible MaterialsTracheaTracheostomyAnimalsCadaverFeasibility StudiesHumansMaterials TestingModels, AnimalSwineBiocompatible MaterialsCough efficacyDecannulation failureMechanical ventilatorsPulmonary rehabilitationRespiratory insufficiencyTracheostomy

Identifiers

PMID41152336
PMCPMC12568967

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.