Evidence map›Paper›PMID 41152333›Full record

ArticleScientific reports2025

Lithium chloride at environmental concentrations impairs microtubule function and promotes genotoxicity in Allium cepa.

Gabriela Gomes Lima, Carlos Filipe Camilo-Cotrim, Junilson Augusto Paula Silva, Myllena Tolentino Firmino, Natanael Alves Silva, Antônio Sérgio Nakao Aguiar, Marcelino Benvindo-Souza, Leonardo Luiz Borges, Samantha Salomão Caramori, Elisa Flávia Luiz Cardoso Bailão and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Gabriela Gomes LimaLaboratório de Biotecnologia, Universidade Estadual de Goiás, BR 153, No. 3105, Fazenda Barreiro do Meio - Henrique Santillo Campus, P.O. Box 459, Anápolis, GO, 75132-400, Brazil.
Carlos Filipe Camilo-CotrimLaboratório de Biotecnologia, Universidade Estadual de Goiás, BR 153, No. 3105, Fazenda Barreiro do Meio - Henrique Santillo Campus, P.O. Box 459, Anápolis, GO, 75132-400, Brazil.
Junilson Augusto Paula SilvaLaboratório de Biotecnologia, Universidade Estadual de Goiás, BR 153, No. 3105, Fazenda Barreiro do Meio - Henrique Santillo Campus, P.O. Box 459, Anápolis, GO, 75132-400, Brazil.
Myllena Tolentino FirminoLaboratório de Biotecnologia, Universidade Estadual de Goiás, BR 153, No. 3105, Fazenda Barreiro do Meio - Henrique Santillo Campus, P.O. Box 459, Anápolis, GO, 75132-400, Brazil.
Natanael Alves SilvaLaboratório de Biotecnologia, Universidade Estadual de Goiás, BR 153, No. 3105, Fazenda Barreiro do Meio - Henrique Santillo Campus, P.O. Box 459, Anápolis, GO, 75132-400, Brazil.
Antônio Sérgio Nakao AguiarLaboratório de Novos Materiais, Universidade Evangélica de Goiás, Anápolis, GO, 75083-515, Brazil.
Marcelino Benvindo-SouzaLaboratório de Biotecnologia, Universidade Estadual de Goiás, BR 153, No. 3105, Fazenda Barreiro do Meio - Henrique Santillo Campus, P.O. Box 459, Anápolis, GO, 75132-400, Brazil.
Leonardo Luiz BorgesGrupo de Química Teórica e Estrutural de Anápolis, Universidade Estadual de Goiás, Anápolis, GO, 75132-903, Brazil.
Samantha Salomão CaramoriLaboratório de Biotecnologia, Universidade Estadual de Goiás, BR 153, No. 3105, Fazenda Barreiro do Meio - Henrique Santillo Campus, P.O. Box 459, Anápolis, GO, 75132-400, Brazil.
Elisa Flávia Luiz Cardoso BailãoLaboratório de Biotecnologia, Universidade Estadual de Goiás, BR 153, No. 3105, Fazenda Barreiro do Meio - Henrique Santillo Campus, P.O. Box 459, Anápolis, GO, 75132-400, Brazil.
Luciane Madureira AlmeidaLaboratório de Biotecnologia, Universidade Estadual de Goiás, BR 153, No. 3105, Fazenda Barreiro do Meio - Henrique Santillo Campus, P.O. Box 459, Anápolis, GO, 75132-400, Brazil. luciane.almeida@ueg.br.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico Rede Hidro-Cerrado (Call No. 20/2023)Universidade Estadual de Goiás Call No. 42/2023 (Institutional Strategic Project - Water Security Program, No. 20/2023), under SEI Process No. 202300020023318
6 · The paper itself

Abstract

The growing demand for lithium, driven by the energy transition and widespread use of rechargeable batteries, has raised concerns about its environmental release. This study assessed the toxicological effects of lithium chloride (LiCl) at environmentally relevant concentrations using the Allium cepa bioassay. While lithium's genotoxicity at high concentrations is known, its effects at levels typical of aquatic systems (up to 4 mg/L) remain poorly understood. A set of biomarkers was applied to evaluate cytotoxicity, genotoxicity, oxidative stress, and in silico molecular interactions. LiCl exposure significantly reduced the mitotic index, indicating cytotoxic effects via impaired cell division. Increased chromosomal aberrations and nuclear abnormalities were observed, particularly at 4 mg/L, suggesting genotoxicity. However, the Comet assay revealed minimal DNA strand breaks, pointing to an aneugenic mechanism likely caused by mitotic spindle disruption rather than clastogenic effects. Cell cycle analysis showed reduced metaphase and increased anaphase frequencies, reinforcing the hypothesis of chromosomal missegregation. In silico modeling demonstrated strong interactions between Li

Indexed as

Lithium ChlorideMicrotubulesOnionsCell CycleChromosome AberrationsDNA DamageMitotic IndexOxidative StressLithium ChlorideAneugenicityCytotoxicityEcotoxicologyEmerging contaminantMicrotubule disruptionOxidative stress

Identifiers

PMID41152333
PMCPMC12569043

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.