Evidence map›Paper›PMID 41152314›Full record

ArticleNPJ breast cancer2025

A core outcome set for locoregional treatment reporting in neoadjuvant systemic breast cancer treatment trials.

Shelley Potter, Kerry Avery, Rosina Ahmed, Jana de Boniface, Sanjoy Chatterjee, David Dodwell, Peter Dubsky, Jingjing Federmann, Sandra Finestone, Michael Gnant and 20 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ breast cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Shelley Potter *Bristol Surgical and Perioperative Care Complex Intervention Collaboration; Bristol Medical School, Bristol, UK. shelley.potter@bristol.ac.uk.
Kerry AveryBristol Surgical and Perioperative Care Complex Intervention Collaboration; Bristol Medical School, Bristol, UK.
Rosina AhmedTata Medical Centre, Kolkata, India.
Jana de BonifaceBreast Unit, Capio St. Göran's Hospital, Stockholm, Sweden.
Sanjoy ChatterjeeTata Medical Centre, Kolkata, India.
David DodwellUniversity of Oxford, Oxford, UK.
Peter DubskyHirslanden Klinik St Anna, Lucerne, Switzerland.
Jingjing FedermannAustrian Breast & Colorectal Cancer Study Group, Vienna, Austria.
Sandra FinestonePatient advocate, California, United States of America.
Michael GnantAustrian Breast & Colorectal Cancer Study Group, Vienna, Austria.
Dominik HlauschekAustrian Breast & Colorectal Cancer Study Group, Vienna, Austria.
Hiroji IwataAichi Cancer Centre, Nagoya, Japan.
Michael Y JiangBristol Surgical and Perioperative Care Complex Intervention Collaboration; Bristol Medical School, Bristol, UK.
Orit Kaidar-PersonBreast Radiation Unit, Sheba Medical Centre, Ramat Gan, Israel; School of Medicine, Faculty of Medical & Health Sciences, Tel-Aviv University, Tel-Aviv, Israel; GROW- Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, Netherlands.
Han-Byoel LeeDept. of Surgery, Seoul National University College of Medicine; Cancer Research Institute, Seoul National University; Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.
Mairead MacKenzieIndependent Cancer Patients' Voice, London, UK.
Anne MeynPatient advocate, California, United States of America.
Philip PoortmansDepartment of Radiation Oncology, Iridium Netwerk, Wilrijk-Antwerp, Belgium; University of Antwerp, Faculty of Medicine and Health Sciences, Wilrijk-Antwerp, Belgium.
Fiorita PoulakakiEuropa Donna - The European Breast Cancer Coalition, Milan, Italy.
Andrea L RichardsonJohn's Hopkins Medicine, Baltimore, USA.
Karla A SepulvedaBaylor College of Medicine, Houston, TX, USA.
Andrew J SpillaneUniversity of Sydney, Sydney, Australia.
Alastair M ThompsonBaylor College of Medicine, Houston, TX, USA.
Gustavo WerutskyLatin American Cooperative Oncology Group, Porto Alegre, Brazil.
Philipp WittmannAustrian Breast & Colorectal Cancer Study Group, Vienna, Austria.
Jean L WrightDepartment of Radiation Oncology at the University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Nicholas ZdenkowskiUniversity of Newcastle, Newcastle, Australia.
Katherine CowanKatherine Cowan Consulting, Thame, UK.
Stuart A McIntosh *Patrick G Johnson Centre for Cancer Research, Queen's University Belfast, Belfast, UK.
PRECEDENT Study Group

Funding

National Institute for Health and Care Research CS-2016-16-019
6 · The paper itself

Abstract

Accurate information about locoregional breast cancer treatments following neoadjuvant systemic therapy (NST) is essential for meaningful interpretation of oncological outcomes but reporting is currently poor. We developed a core outcome set (COS) to improve the quality and consistency of locoregional outcome reporting in breast cancer NST trials. The COS was developed in three phases according to COS-STAD guidance, with the generation of a list of relevant outcome domains, prioritisation of outcomes through two rounds of an international online multi-stakeholder Delphi survey and a consensus meeting. 159 unique locoregional outcomes were classified into 101 outcome domains for inclusion in the Delphi survey, which was completed by 470 international professionals. The final 15-item COS, which included the pre-NST surgical plan, details of surgery performed following completion of treatment and details of radiation therapy, was agreed at an in-person consensus meeting. Widespread COS implementation will improve the quality and value of future NST trials.

Identifiers

PMID41152314
PMCPMC12568921

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.