Evidence map›Paper›PMID 41152298›Full record

ArticleScientific reports2025

Mapping NK cell diversity in response to COVID-19 and mRNA vaccination.

Yosuke Kishi, Yu-Chen Liu, Masakazu Ishikawa, Maika Yamashita, Hisatake Matsumoto, Hiroshi Ogura, Shuhei Sakakibara, Daisuke Okuzaki

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yosuke KishiLaboratory for Human Immunology (Single Cell Genomics), Immunology Frontier Research Center, The University of Osaka, Osaka, Japan.
Yu-Chen LiuLaboratory for Human Immunology (Single Cell Genomics), Immunology Frontier Research Center, The University of Osaka, Osaka, Japan.
Masakazu IshikawaLaboratory for Human Immunology (Single Cell Genomics), Immunology Frontier Research Center, The University of Osaka, Osaka, Japan.
Maika YamashitaLaboratory for Human Immunology (Single Cell Genomics), Immunology Frontier Research Center, The University of Osaka, Osaka, Japan.
Hisatake MatsumotoDepartment of Traumatology and Acute Critical Medicine, Graduate School of Medicine, The University of Osaka, Osaka, Japan.
Hiroshi OguraDepartment of Traumatology and Acute Critical Medicine, Graduate School of Medicine, The University of Osaka, Osaka, Japan.
Shuhei SakakibaraLaboratory of Systems Immunology, Immunology Frontier Research Center, The University of Osaka, Osaka, Japan. sakakibara@ifrec.osaka-u.ac.jp.
Daisuke OkuzakiLaboratory for Human Immunology (Single Cell Genomics), Immunology Frontier Research Center, The University of Osaka, Osaka, Japan. dokuzaki@ifrec.osaka-u.ac.jp.

Funding

Japan Agency for Medical Research and Development JP22gm1810003h0001
6 · The paper itself

Abstract

Human NK cells exhibit functional heterogeneity, yet the clinical conditions and cellular processes driving this diversity remain insufficiently understood. Here, we report that NK cell diversity emerges during peripheral development, influenced by the divergence of adaptive NK cells from various stages of canonical NK cell maturation during the resolution phase of severe COVID-19. Using scRNA-seq, we analyzed blood NK cells from patients with severe COVID-19 (acute phase and post-intensive care), individuals vaccinated with the SARS-CoV-2 mRNA vaccine (BNT162b2), and healthy donors. The frequencies of immature CD56

Indexed as

COVID-19COVID-19 VaccinesKiller Cells, NaturalSARS-CoV-2AdultBNT162 VaccineCD56 AntigenFemaleHumansMaleMiddle AgedVaccinationBNT162 VaccineCD56 AntigenCOVID-19 VaccinesCOVID-19mRNA vaccineNK cellsscRNA-seqTrajectory analysis

Identifiers

PMID41152298
PMCPMC12568986

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.