ArticleNature communications2025
Multi-lens ultrasound arrays enable large scale three-dimensional micro-vascularization characterization over whole organs.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- What Does the Photoplethysmography Add to Laser Doppler Flowmetry During the Brachial Artery Occlusion Test?Journal of biophotonics · 2026Article
- Bridging precision agriculture and human medicine through comparative genetics.Nature reviews. Genetics · 2026Review
- A novel electrocardiogram-synchronized laser Doppler holography system for cardiac cycle-resolved retinal hemodynamics: development and validation.Scientific reports · 2026Article
- Large elements and advanced beamformers for increased field of view in 2-D ultrasound matrix arrays.ArXiv · 2026Article
- Multi-lens ultrasound arrays enable large scale three-dimensional micro-vascularization characterization over whole organs.Nature communications · 2025Article
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Authors and funding
12 authors.
Funding
Abstract
Mapping microcirculation at the whole-organ scale in 3D is crucial for understanding vascular pathologies and improving diagnostics. Although 3D ultrasound localization microscopy (ULM) enables microscopic resolution by localizing intravenously injected microbubbles in small animal models, visualizing entire organs in large animals or humans remains challenging due to limited field of view, low sensitivity, and probe technological complexity. Here, we demonstrate how a multi-lens array method overcomes these limitations. Combined with 3D ULM, it maps and quantifies large vascular volumes (up to 120 × 100 × 82 mm³) at high spatial resolution (125-200 µm) with a volumetric acquisition rate of 312 Hz, using low-cost technology. This approach enables deeper insights into hemodynamics from large vessels to pre-capillary arterioles, by providing vast and rich datasets of whole-organ vascularization. It could also facilitate diagnosis of microcirculation disorders and monitoring of small-vessel disease treatments by addressing key limitations of current imaging modalities.
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Registered trials
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