Evidence map›Paper›PMID 41152242›Full record

ArticleNature communications2025

Plasmid dynamics driving carbapenemase gene dissemination in healthcare environments: a nationwide analysis of closed Enterobacterales genomes.

Vanessa Koh, Rodrigo Cabrera, Prakki Sai Rama Sridatta, Natascha May Thevasagayam, Ze Qin Lim, Kalisvar Marimuthu, Indumathi Venkatachalam, Benjamin Pei Zhi Cherng, Raymond Kok Choon Fong, Surinder Kaur Pada and 18 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Frontiers in bioinformatics · 2026
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Vanessa KohNCID Research Office, National Centre for Infectious Diseases, Singapore, Singapore.ORCID http://orcid.org/0009-0006-3100-0435
Rodrigo CabreraSchool of Medicine and Health Sciences, Center for Research in Genetics and Genomics (CIGGUR), Institute of Translational Medicine (IMT), Universidad Del Rosario, Bogotá, Colombia.
Prakki Sai Rama SridattaNCID Research Office, National Centre for Infectious Diseases, Singapore, Singapore.
Natascha May ThevasagayamNCID Research Office, National Centre for Infectious Diseases, Singapore, Singapore.
Ze Qin LimNCID Research Office, National Centre for Infectious Diseases, Singapore, Singapore.
Kalisvar MarimuthuDepartment of Infectious Diseases, National Centre for Infectious Diseases, Singapore, Singapore.
Indumathi VenkatachalamDepartment of Infectious Diseases, Singapore General Hospital, Singapore, Singapore.
Benjamin Pei Zhi CherngYong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.
Raymond Kok Choon FongDepartment of Infectious Diseases, Changi General Hospital, Singapore, Singapore.
Surinder Kaur PadaDepartment of Infectious Diseases, Ng Teng Fong General Hospital, Singapore, Singapore.
Say Tat OoiDivision of Infectious Diseases, Department of General Medicine, Khoo Teck Puat Hospital, Singapore, Singapore.
Nares SmitasinYong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.
Koh Cheng ThoonInfectious Diseases Service, KK Women's and Children's Hospital, Singapore, Singapore.
Li Yang HsuYong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.
Tse Hsien KohDepartment of Microbiology, Singapore General Hospital, Singapore, Singapore.
Partha Pratim DeDepartment of Laboratory Medicine, Tan Tock Seng Hospital, Singapore, Singapore.
Thean Yen TanDepartment of Laboratory Medicine, Changi General Hospital, Singapore, Singapore.
Douglas ChanDepartment of Laboratory Medicine, Ng Teng Fong General Hospital, Singapore, Singapore.
Rama Narayana DeepakDepartment of Laboratory Medicine, Khoo Teck Puat Hospital, Singapore, Singapore.
Nancy Wen Sim TeeDepartment of Laboratory Medicine, National University Hospital and National University Health System, Singapore, Singapore.
Yunn-Hwen GanInfectious Diseases Translational Research Program, Department of Biochemistry, National University of, Singapore, Singapore.ORCID http://orcid.org/0000-0001-9881-6881
William MatlockDepartment of Biology, University of Oxford, Oxford, United Kingdom.ORCID http://orcid.org/0000-0001-5608-0423
David W EyreNuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.ORCID http://orcid.org/0000-0001-5095-6367
Michelle AngNational Public Health Laboratory, National Centre for Infectious Diseases, Singapore, Singapore.
Raymond Tzer Pin LinDepartment of Laboratory Medicine, National University Hospital and National University Health System, Singapore, Singapore.ORCID http://orcid.org/0000-0001-6654-026X
Jeanette TeoDepartment of Laboratory Medicine, National University Hospital and National University Health System, Singapore, Singapore.
Oon Tek NgDepartment of Infectious Diseases, National Centre for Infectious Diseases, Singapore, Singapore. oon.tek.ng@nhghealth.com.sg.
Carbapenemase-Producing Enterobacteriaceae in Singapore (CaPES) Study Group

Funding

MOH | National Medical Research Council (NMRC) CG21APR2005MOH | National Medical Research Council (NMRC) MOH-001326-01MOH | National Medical Research Council (NMRC) MOH-001706MOH | National Medical Research Council (NMRC) MOH-001763
6 · The paper itself

Abstract

Plasmid-mediated transmission can account for half of carbapenem-producing Enterobacterales (CPE) dissemination, underscoring the need to identify genetic determinants of plasmid persistence in the hospital setting. From 1,088 CPE isolates detected through nationwide surveillance in Singapore over five years, 1,115 closed carbapenemase-producing plasmids were identified and clustered, of which 92.5% (n = 1031) were grouped into 48 plasmid clusters (PCs). The most common plasmid genotypes were PC1 and PC2. Of 389 isolates carrying bla

Indexed as

Bacterial Proteinsbeta-LactamasesEnterobacteriaceaeEnterobacteriaceae InfectionsGenome, BacterialPlasmidsCarbapenem-Resistant EnterobacteriaceaeCarbapenemsGene Transfer, HorizontalGenotypeHumansMicrobial Sensitivity TestsSingaporeBacterial Proteinsbeta-lactamase NDM-1beta-LactamasescarbapenemaseCarbapenems

Identifiers

PMID41152242
PMCPMC12569050

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.