Evidence map›Paper›PMID 41152235›Full record

ArticleNature communications2025

A dynamic biointerface in mussels mediated by a mechanoresponsive intermediate filament-based biopolymer.

Lucia Youssef, Jenaes Sivasundarampillai, Emily N P Prowse, E Deniz Eren, Franziska Jehle, Christopher Thibodeaux, Adam G Hendricks, Daniel J Jackson, Matthew J Harrington

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lucia YoussefDepartment of Chemistry, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0009-0006-3415-9206
Jenaes SivasundarampillaiDepartment of Chemistry, McGill University, Montreal, QC, Canada.
Emily N P ProwseDepartment of Bioengineering, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0002-7127-5146
E Deniz ErenDepartment of Chemistry, McGill University, Montreal, QC, Canada.
Franziska JehleDepartment of Chemistry, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0001-5960-0850
Christopher ThibodeauxDepartment of Chemistry, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0002-4792-8362
Adam G HendricksDepartment of Bioengineering, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0003-3635-1577
Daniel J JacksonDepartment of Geobiology, Georg-August University of Göttingen, Göttingen, Germany.ORCID http://orcid.org/0000-0001-9045-381X
Matthew J HarringtonDepartment of Chemistry, McGill University, Montreal, QC, Canada. matt.harrington@mcgill.ca.ORCID http://orcid.org/0000-0003-1417-9251

Funding

Canada Research Chairs (Chaires de recherche du Canada) CRC Tier 2 950-231953
6 · The paper itself

Abstract

Mussels fabricate a distinctive biointerface that bridges their non-living biopolymeric byssus (used for anchoring in seashore habitats) with their soft-living tissue. Occurring in a region known as the byssus stem root, this biointerface is at once strong, yet also capable of on-demand release under apparent neurobiological control by the mussel, but this is not well understood. Here, we identify and sequence a previously unknown intermediate filament protein (MSP-1) that based on immunohistochemical staining and spectroscopic mapping comprises the surface of the stem root in direct contact with billions of motile cilia emerging from the living tissue. Further structural analysis indicates that MSP-1 is secreted as an α-helical coiled-coil but is mechanically converted subsequently to a β-sheet conformation. We posit that this mechanoresponsive conversion has a mechanical function in toughening the interface, but possibly also as a mechanosensory mechanism given its intimate contact with cilia in the living tissue.

Indexed as

BivalviaIntermediate Filament ProteinsIntermediate FilamentsAnimalsBiopolymersCiliaMechanotransduction, CellularBiopolymersIntermediate Filament Proteins

Identifiers

PMID41152235
PMCPMC12568988

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.