Evidence map›Paper›PMID 41152112›Full record

ArticleJournal of the Formosan Medical Association = Taiwan yi zhi2026

Neuronal-specific antibody in patients with multiple system atrophy and progressive supranuclear palsy.

Mimi S Fang, Ming-Chen Tsai, Friederike A Arlt, Cheng-Hsuan Li, Sung-Pin Fan, Pin-Shiuan Chen, Yang-Yee Chang, Min-Yu Lan, Yih-Ru Wu, Ing-Tsung Hsiao and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Formosan Medical Association = Taiwan yi zhi, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Anti-Sez6L2 antibody-associated autoimmune cerebellar ataxia: a rare case with implications of rituximab therapy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Mimi S FangDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Ming-Chen TsaiDivisions of Child and Adolescent Neurology and Epilepsy, Department of Neurology, Mayo Clinic, Rochester, MN, USA; Department of Neurology, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan; Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Friederike A ArltDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA; Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Cheng-Hsuan LiDepartment of Neurology, National Taiwan University Hospital, Taipei, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
Sung-Pin FanDepartment of Neurology, National Taiwan University Hospital, Taipei, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
Pin-Shiuan ChenDepartment of Neurology, National Taiwan University Hospital, Taipei, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Neurology, National Taiwan University Hospital Bei-Hu Branch, Taipei, Taiwan.
Yang-Yee ChangDepartment of Neurology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Min-Yu LanDepartment of Neurology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Yih-Ru WuDepartment of Neurology, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Ing-Tsung HsiaoNuclear Medicine and Center for Advanced Molecular Imaging and Translation, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan.
Han-Lin ChiangDivision of General Neurology, Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Chun-Yu ChenDivision of General Neurology, Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Tsung-Lin LeeDepartment of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Biomedical Engineering, National Cheng Kung University, Tainan, Taiwan.
Hsiu-Chen ChangProfessor Lu Neurological Clinic, Taoyuan, Taiwan.
Jung-Lung HsuDepartment of Neurology, New Taipei Municipal Tucheng Hospital (built and Operated by Chang Gung Medical Foundation), New Taipei, Taiwan.
Chin-Song LuProfessor Lu Neurological Clinic, Taoyuan, Taiwan; Department of Neurology, Landseed International Hospital, Taoyuan, Taiwan.
Andrew McKeonDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA; Department of Neurology, Mayo Clinic, Rochester, MN, USA. Electronic address: McKeon.Andrew@mayo.edu.
Chin-Hsien LinDepartment of Neurology, National Taiwan University Hospital, Taipei, Taiwan; Graduate Institute of Biomedical Engineering, College of Medical Science and Technology, National Taiwan University, Taipei, Taiwan; Graduate Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address: chlin@ntu.edu.tw.
Taiwan PSP/CBS consortium

Funding

Seronegative Autoimmune Encephalopathies: Biomarker Discovery, Validation & Deep PhenotypingR01NS126227 · NINDS · MAYO CLINIC ROCHESTER · PI Andrew McKeon · 2022 to 2026
$1.9M
NINDS NIH HHS R01 NS126227
6 · The paper itself

Abstract

Anti-neuronal antibodies can manifest with diverse movement disorders, including parkinsonism and ataxia, and may mimic neurodegeneration. The prevalence of neuronal-specific antibodies in atypical parkinsonism remains unclear. We examined 166 patients, including 136 patients with clinically diagnosed progressive supranuclear palsy (PSP) and 30 patients with multiple system atrophy (MSA) from the Taiwan PSP/CBS Consortium using an integrated set of tissue-based immunofluorescence assays and a subsequent fixed cell-based assay as well as confirmatory tests to detect neuronal-specific antibodies. We observed one PSP-Richardson syndrome patient (0.74 %) was CASPR2-IgG positive, and one MSA-cerebellar subtype patient (3.33 %) showed GAD65 positivity with a hot-cross bun sign on MRI. The latter showed clinical improvement after immunotherapy. Neither patient had sleep-related symptoms. These findings indicate that neuronal-specific antibodies may mimic MSA or PSP and warrant antibody testing in atypical parkinsonism to identify reversible autoimmune causes.

Indexed as

AutoantibodiesMultiple System AtrophyNeuronsSupranuclear Palsy, ProgressiveAgedAged, 80 and overDiagnosis, DifferentialFemaleFluorescent Antibody TechniqueHumansMagnetic Resonance ImagingMaleMiddle AgedTaiwanAutoantibodiesAnti-neuronal antibodyMultiple system atrophyProgressive supranuclear palsy

Identifiers

PMID41152112
PMCPMC12626099

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.