Evidence map›Paper›PMID 41152026›Full record

ArticleBritish journal of haematology2026

Cerebral blood flow trajectories in paediatric sickle cell anaemia by age, region, and treatment associations.

Ping Zou Stinnett, Robert J Ogg, Kathleen Helton, Winfred Wang, Andrew M Heitzer, Zachary Abramson, Yimei Li, Tushar Patni, Paul VanGilder, Akshay Sharma and 1 more

Abstract read
In one paragraph

Article in British journal of haematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ping Zou StinnettSt. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID https://orcid.org/0000-0002-3472-0001
Robert J OggSt. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Kathleen HeltonSt. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Winfred WangSt. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Andrew M HeitzerSt. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Zachary AbramsonSt. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Yimei LiSt. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Tushar PatniSt. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Paul VanGilderSt. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Akshay SharmaSt. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Ranganatha SitaramSt. Jude Children's Research Hospital, Memphis, Tennessee, USA.

Funding

School Readiness Intervention for Preschool Children with Sickle Cell DiseaseK23HL166697 · NHLBI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Andrew M Heitzer · 2023 to 2026
$648k
American Lebanese Syrian Associated CharitiesNCI NIH HHS CA21765NCRR NIH HHS RR029005NHLBI NIH HHS K23 HL166697
6 · The paper itself

Abstract

Opposite to the age trend in healthy children, cerebral blood flow increases with age in children with sickle cell anaemia. Early treatment with hydroxyurea (hydroxycarbamide) may help slow this abnormal trend and protect brain functions.

Indexed as

Anemia, Sickle CellCerebrovascular CirculationHydroxyureaAdolescentAge FactorsAntisickling AgentsChildChild, PreschoolFemaleHumansMaleAntisickling AgentsHydroxyureacerebral blood flowhydroxyurea (hydroxycarbamide)paediatricsickle cell anaemia

Identifiers

PMID41152026
PMCPMC12819090

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.