Evidence map›Paper›PMID 41151993›Full record

ReviewEuropean journal of haematology2026

Primary Cutaneous B-Cell Lymphomas: An Updated Portrait of Classification, Biology, and Clinical Management.

A Bernardelli, E Carazzai, B Bugnotto, F Bellinato, M Krampera, C Visco

Abstract readReview
In one paragraph

Review in European journal of haematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

A BernardelliUOC di Ematologia e CTMO, DAI Medico Generale, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy.ORCID https://orcid.org/0000-0002-4444-8339
E CarazzaiHematology and Bone Marrow Transplant Unit, Section of Biomedicine of Innovation, Department of Engineering for Innovative Medicine (DIMI), University of Verona, Verona, Italy.
B BugnottoHematology and Bone Marrow Transplant Unit, Section of Biomedicine of Innovation, Department of Engineering for Innovative Medicine (DIMI), University of Verona, Verona, Italy.
F BellinatoSection of Dermatology and Venereology, Department of Medicine, University of Verona, Verona, Italy.
M KramperaUOC di Ematologia e CTMO, DAI Medico Generale, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy.ORCID https://orcid.org/0000-0002-7280-2040
C ViscoUOC di Ematologia e CTMO, DAI Medico Generale, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary cutaneous B-cell lymphomas (CBCL) represent a clinically and biologically heterogeneous group of extranodal non-Hodgkin lymphomas confined to the skin at the time of diagnosis. They account for approximately 25% of all primary cutaneous lymphomas and are subclassified into distinct entities according to the World Health Organization-European Organization of Research and Treatment of Cancer (WHO-EORTC) classification and International Consensus Classification (ICC). including primary cutaneous follicle center lymphoma (PCFCL), primary cutaneous marginal zone lymphoma (PCMZL), primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT), intravascular large B-cell lymphoma (IVLBCL) and Epstein-Barr virus-positive mucocutaneous ulcer (EBVMCU). These subtypes differ significantly in clinical behavior, histopathological features, molecular alterations, and prognosis. Indolent forms such as PCFCL and PCMZL are typically managed with local therapies and are associated with an excellent prognosis. In contrast, aggressive variants such as PCDLBCL-LT require systemic treatment and are linked to poorer outcomes. EBVMCU, despite its alarming histological appearance, generally follows a benign and self-limiting course. This review provides an updated overview of the current diagnostic criteria, clinical management strategies, and emerging molecular insights for each CBCL subtype. It also emphasizes the importance of a multidisciplinary approach and discusses the challenges of prognostication, along with the evolving but still limited role of innovative therapies.

Indexed as

Lymphoma, B-CellSkin NeoplasmsBiomarkers, TumorDisease ManagementEpstein-Barr Virus InfectionsHumansNeoplasm StagingPrognosisTreatment OutcomeBiomarkers, TumorB‐cell neoplasmscutaneous B‐cell lymphomamultidisciplinary managementrare cutaneous lymphomastargeted therapies

Identifiers

PMID41151993
PMCPMC12781160

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.