Evidence map›Paper›PMID 41151958›Full record

ArticleBMJ open2025

Association between normal systolic blood pressure maintenance and the risk of coronary artery calcification progression in asymptomatic non-diabetic and diabetic adults: a retrospective cohort study using data from the Korea initiatives on coronary artery calcification registry.

Ki-Bum Won, Su-Yeon Choi, Eun Ju Chun, Sung Hak Park, Jidong Sung, Hae Ok Jung, Hyuk Jae Chang

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Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Ki-Bum WonChung-Ang University College of Medicine, Dongjak-gu, Seoul, Republic of Korea.
Su-Yeon ChoiInternal Medicine, Seoul National University Hospital, Jongno-gu, Seoul, Republic of Korea.
Eun Ju ChunSeoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea.
Sung Hak ParkGangnam Heartscan Clinic, Seoul, Republic of Korea.
Jidong SungSamsung Medical Center, Gangnam-gu, Republic of Korea.
Hae Ok JungThe Catholic University of Korea, Jongno-gu, Republic of Korea.
Hyuk Jae ChangYonsei University Health System, Seodaemun-gu, Republic of Korea hjchang@yuhs.ac.ORCID http://orcid.org/0000-0002-6139-7545

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo assess the association of normal systolic blood pressure maintenance (SBP

designRetrospective cohort study with a mean follow-up of 3.3 years.

settingData from the Korea Initiatives on Coronary Artery Calcification registry were analysed.

participants10 754 asymptomatic Korean adults (51.5±8.6 years; 84.5% male; 14.2% diabetes) were enrolled. Participants were divided into two groups: normal SBP

main outcome measuresCAC progression was defined as a difference of ≥2.5 between the square roots (√) of the baseline and follow-up coronary artery calcium score (CACS) (Δ√transformed CACS). Annualised Δ√transformed CACS was defined as Δ√transformed CACS divided by the interscan period.

resultsCompared with non-diabetics, the incidence of CAC progression was higher in diabetics (28.4% vs 47.3%, p<0.001) during a mean follow-up of 3.3 years. Normal SBP

conclusionsMaintaining normal systolic blood pressure was associated with a significantly attenuated CAC progression, especially in clinical conditions without established diabetes.

Indexed as

Blood PressureCoronary Artery DiseaseDiabetes MellitusVascular CalcificationAdultAgedDisease ProgressionFemaleHumansMaleMiddle AgedRegistriesRepublic of KoreaRetrospective StudiesRisk FactorsBlood PressureCoronary heart diseaseDiabetes Mellitus, Type 2Primary Prevention

Identifiers

PMID41151958
PMCPMC12570917

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