Evidence map›Paper›PMID 41151927›Full record

ArticleJournal of clinical neurology (Seoul, Korea)2025

Analysis of Gut Microbiota and Their Metabolites in CADASIL Patients.

Akiko Watanabe-Hosomi, Ryo Inoue, Ikuko Mizuta, Jun Matsuura, Hiraku Matsuura, Daiki Fukunaga, Tomoyuki Ohara, Yuji Naito, Toshiki Mizuno

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical neurology (Seoul, Korea), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Gut Microbiota and CADASIL: Emerging Insights and Future Directions.Journal of clinical neurology (Seoul, Korea) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Akiko Watanabe-HosomiDepartment of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.ORCID https://orcid.org/0009-0001-8497-5723
Ryo InoueLaboratory of Animal Science, Department of Applied Biological Sciences, Faculty of Agriculture, Setsunan University, Hirakata, Japan.ORCID https://orcid.org/0000-0002-7233-366X
Ikuko MizutaDepartment of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.ORCID https://orcid.org/0000-0002-2775-2507
Jun MatsuuraDepartment of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.ORCID https://orcid.org/0000-0002-5127-9473
Hiraku MatsuuraDepartment of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.ORCID https://orcid.org/0000-0003-3476-1820
Daiki FukunagaDepartment of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.ORCID https://orcid.org/0000-0002-1753-7598
Tomoyuki OharaDepartment of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.ORCID https://orcid.org/0000-0002-8116-4730
Yuji NaitoDepartment of Human Immunology and Nutrition Science, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.ORCID https://orcid.org/0000-0001-5443-788X
Toshiki MizunoDepartment of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan. mizuno@koto.kpu-m.ac.jp.ORCID https://orcid.org/0000-0002-7907-8243

Funding

Japan Society for the Promotion of Science 20K07872
6 · The paper itself

Abstract

background and purposeCerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a major hereditary small-vessel disease caused by mutations in

methodsWe performed 16S rRNA sequencing of gut microbiota in the 24 patients and 17 controls. Of these, 15 patients and 13 controls underwent analyses of fecal metabolites.

resultsAmong the 24 CADASIL patients and 17 controls recruited, 16S rRNA sequencing of fecal samples revealed a significant difference in b-diversity (

conclusionsBoth indole and

Indexed as

CADASILdysbiosisgastrointestinal microbiomeimportant terms

Identifiers

PMID41151927
PMCPMC12569424

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.