Evidence map›Paper›PMID 41151865›Full record

ArticleCancer genomics & proteomics

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Marilyn D Saulsbury, Simone O Heyliger, Emanuela Taioli, Tamiel N Turley, Jordan P Reynolds, John A Copland, Adam M Kase, R Renee Reams

Abstract read
In one paragraph

Article in Cancer genomics & proteomics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. ReducedCancer diagnosis & prognosis
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marilyn D SaulsburySchool of Pharmacy, Department of Pharmaceutical Sciences, Hampton University, Hampton, VA, U.S.A.
Simone O HeyligerSchool of Pharmacy, Department of Pharmaceutical Sciences, Hampton University, Hampton, VA, U.S.A.
Emanuela TaioliDepartment of Thoracic Surgery, Tisch Cancer Institute and Institute for Translational Epidemiology, Icahn School of Medicine at Mount Sinai, New York, NY, U.S.A.
Tamiel N TurleyCancer Biology Department, Mayo Clinic, Jacksonville, FL, U.S.A.
Jordan P ReynoldsDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL, U.S.A.
John A CoplandCancer Biology Department, Mayo Clinic, Jacksonville, FL, U.S.A.
Adam M Kase *Hematology/Oncology Division, Internal Medicine Department, Mayo Clinic Comprehensive Cancer Center, Jacksonville Mayo Clinic, Jacksonville, FL, U.S.A.; kase.adam@mayo.edu.
R Renee Reams *College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL, U.S.A.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimClear cell renal cell carcinoma (ccRCC), the most prevalent form of kidney cancer, often presents or recurs as an advanced, aggressive, and lethal disease. Thus, biomarkers are needed to identify patients at risk of developing advanced-stage or treatment-resistant ccRCC. SYNJ2BP, a cytoplasmic scaffolding protein, regulates ACVR2 activity, a key mediator of signaling pathways involved in tumor progression and metastasis. This study aimed to ascertain if MATERIALS AND

methodsBioinformatic analysis and immunohistochemistry were applied to investigate the relationship between SYNJ2BP expression, the immune landscape, and survival outcomes in ccRCC. We utilized data from publicly available databases, including The Cancer Genome Atlas, Gene Set Cancer Analysis (TCGA), and various other databases.

resultsIn-silico analyses revealed that

conclusionSYNJ2BP is a novel prognostic biomarker for ccRCC and the down-regulation of

Indexed as

Biomarkers, TumorCarcinoma, Renal CellKidney NeoplasmsAgedComputational BiologyFemaleGene Expression Regulation, NeoplasticHumansMaleMiddle AgedPrognosisBiomarkers, TumorACVR2biomarkersccRCCmitochondriaphosphatidylinositol signalingrenal carcinomaSYNJ2BPtreatment response

Identifiers

PMID41151865
PMCPMC12577599

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.