Evidence map›Paper›PMID 41151859›Full record

ArticleCancer genomics & proteomics

Genomic Features of Cervical Cancer in Okinawa, Japan: Preliminary Findings From 23 Patients.

Hitoshi Maemoto, Shugo Sakihama, Kennosuke Karube, Wataru Kudaka, Tomoko Nakamoto, Yusuke Taira, Yoshihisa Arakaki, Yuko Shimoji, Akihiro Nishie

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In one paragraph

Article in Cancer genomics & proteomics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hitoshi MaemotoDivision of Radiation Oncology, NHO Okinawa Hospital, Okinawa, Japan; maemotohitoshi2@gmail.com.
Shugo SakihamaLaboratory of Hematoimmunology, School of Health Science, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.
Kennosuke KarubeDepartment of Pathology and Laboratory Medicine, Graduate School of Medicine, Nagoya University, Nagoya, Japan.
Wataru KudakaDepartment of Obstetrics and Gynecology, Graduate School of Medical Science, University of the Ryukyus, Okinawa, Japan.
Tomoko NakamotoDepartment of Obstetrics and Gynecology, Graduate School of Medical Science, University of the Ryukyus, Okinawa, Japan.
Yusuke TairaDepartment of Obstetrics and Gynecology, Graduate School of Medical Science, University of the Ryukyus, Okinawa, Japan.
Yoshihisa ArakakiDepartment of Obstetrics and Gynecology, Graduate School of Medical Science, University of the Ryukyus, Okinawa, Japan.
Yuko ShimojiDepartment of Obstetrics and Gynecology, Graduate School of Medical Science, University of the Ryukyus, Okinawa, Japan.
Akihiro NishieDepartment of Radiology, Graduate School of Medical Science, University of the Ryukyus, Okinawa, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimRegional differences in genomic mutation profiles of uterine cervical cancer have been reported. Japanese people are divided into two genetic background clusters, originating from mainland Japan and Okinawa. Okinawa is an island prefecture surrounded by the sea, located more than 800 km from the southernmost point of mainland Japan. No studies have examined gene mutation profiles of cervical cancer in Okinawa. This study aimed to investigate the mutation profile of cervical cancer in Okinawa. PATIENTS AND

methodsTwenty-three patients with biopsy-proven squamous cell carcinoma and adenocarcinoma of the intact uterine cervix who were treated with definitive radiotherapy were analyzed. Genomic DNA was extracted from fresh frozen tissue samples collected by tumor biopsy prior to treatment. Variants of 224 cancer-related genes were identified using next-generation sequencing.

resultsA total of 29 gene mutations were observed in 16 patients, including nine genes mutated in multiple samples:

conclusionGene mutation profiles of cervical cancer in Okinawa may differ from those in other regions.

Indexed as

Biomarkers, TumorMutationUterine Cervical NeoplasmsAdultAgedFemaleGenomicsHigh-Throughput Nucleotide SequencingHumansJapanMiddle AgedPrognosisBiomarkers, TumorCervical cancerchemoradiotherapyDNA sequencegenomeradiotherapy

Identifiers

PMID41151859
PMCPMC12577608

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.