ArticleJournal of biomaterials applications2026
Osteogenic differentiation by pre-osteoblasts is enhanced more on 3D-PRINTED poly-ɛ-caprolactone scaffolds coated with collagen and hydroxyapatite than on poly-ɛ-caprolactone/hydroxyapatite composite scaffolds coated with collagen.
Article in Journal of biomaterials applications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Influence of cell culture parameters on oxygen diffusion and cell distribution in 3D-porous scaffolds for bone tissue engineering: finite element modeling and experimental verification.Medical & biological engineering & computing · 2026Article
- PLA/Collagen/Hydroxyapatite Ternary Biocomposites for Biodegradable Bone Screw Applications.Polymers · 2026Article
- Bone tissue regeneration: role of osteocyte mechanosensing and mechanotransduction.Stem cells translational medicine · 2026Review
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5 authors.
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Abstract
Three-dimensional (3D)-printed poly-ε-caprolactone (PCL) scaffolds lack sufficient bioactivity for optimal bone tissue engineering applications. This shortcoming can be overcome by coating PCL scaffolds with collagen and hydroxyapatite (PCL/col-HA) or by applying a collagen coating to PCL-HA composite scaffolds (PCL-HA/col). Here we aimed to test which type of scaffold is more effective in stimulating osteogenic activity. Moreover, the scaffolds' physicomechanical properties were characterized. 3D-printed PCL/col-HA containing 10, 20, or 30% HA particles, and 3D-printed PCL-HA/col containing 10, 20, or 30% HA particles with collagen coating were fabricated. MC3T3-E1 pre-osteoblasts were cultured on the scaffolds for 14 days. The physicomechanical properties of the scaffolds and pre-osteoblast functionality were evaluated through experiments and finite element (FE) modeling. We found that coating of PCL scaffolds with collagen and HA or coating of PCL-HA composite scaffolds with collagen changed the geometry and topography of the scaffold surfaces. Furthermore, PCL/col-HA and PCL-HA/col showed higher surface roughness and elastic modulus, but lower water contact angle, than PCL scaffolds. FE-modeling showed that all scaffolds tolerated up to 2% compressive strain, which was lower than their yield stress. 3D-printed PCL/col-HA and PCL-HA/col scaffolds promoted pre-osteoblast proliferation and osteogenic activity compared to unmodified PCL scaffolds. PCL-HA/col scaffolds increased pre-osteoblast proliferation and collagen deposition, whereas PCL/col-HA scaffolds increased alkaline phosphatase activity and calcium deposition. Osteogenic activity of pre-osteoblasts was more enhanced on 3D-printed PCL/col-HA scaffolds than on PCL-HA/col scaffolds, particularly in the short-term, which seems promising for
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