ArticleJournal of the Royal Society, Interface2025
Dynamics of brain valves: ostensible rectification mechanisms for cerebrospinal fluid flow.
Article in Journal of the Royal Society, Interface, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- New integrated three-interface conceptual model for clearance and immune surveillance in the human CNS.Frontiers in cell and developmental biology · 2026Review
- Dynamics of brain valves: ostensible rectification mechanisms for cerebrospinal fluid flow.Journal of the Royal Society, Interface · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The flow of cerebrospinal fluid (CSF) through perivascular spaces (PVSs) is an important part of the brain's system for clearing metabolic waste. Astrocyte endfeet ensheath the PVSs of penetrating arteries, separating them from brain extracellular space (ECS). Gaps between astrocyte endfeet could provide a low-resistance pathway for fluid transport across the endfoot wall. Recent research suggests that the astrocyte endfeet may also function as valves that rectify the CSF flow, allowing oscillatory pressures to drive net flows like those observed in experiments. In this study, we employ fluid-structure interaction modelling to investigate the endfoot valve mechanism. Due to the unavailability of precise
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Registered trials
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