ReviewNeuroscience2025
Dementia prevention requires moving beyond individual choice: the costs of effort and time intersect with social determinants of health.
Review in Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Brain health strategies in middle-aged individuals with mild neurocognitive disorder: a scoping review.The journal of prevention of Alzheimer's disease · 2026Review
- Social vulnerability shapes deep clinical phenotypes and brain health in aging and dementia across Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The exposome of brain aging across 34 countries.Nature medicine · 2026Article
- Scientific knowledge about dementia: From the Global South to the world.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors.
Funding
Abstract
Social determinants of health strongly influence modifiable risk factors for dementia, yet prevention frameworks list only individual-level behaviours and conditions, overlooking the impact of social and environmental factors on the risk of dementia. In this perspective, we introduce the concept of non-monetary costs as a central mechanism through which social determinants shape modifiable risk factors by influencing individuals' ability to adopt healthy behaviours. Drawing from economic theory, we define non-monetary costs as the time and metabolic cost, perceived by individuals as physical and cognitive effort, required to engage in healthy behaviours. Under adverse social determinants of health, individuals effectively lack choice, as the non-monetary costs required to engage in healthy behaviours become prohibitively high. We propose a framework that links social determinants of health adversity to increased dementia risk through non-monetary costs. We apply this framework to each of the fourteen modifiable risk factors for dementia identified by the Lancet Commission, demonstrating how these costs systematically elevate risk in populations facing social adversity. Finally, we explore the implications of incorporating non-monetary cost assessments across research, interventions, clinical care, and public policy. We propose that quantifying and addressing these costs is essential for designing equitable, scalable, and contextually grounded strategies for dementia prevention across socially diverse populations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.