Evidence map›Paper›PMID 41151667›Full record

ReviewNeuroscience2025

Dementia prevention requires moving beyond individual choice: the costs of effort and time intersect with social determinants of health.

Joaquín Migeot, Daniel Araya-Ríos, Matias Montecinos, Sandra Baez, María Isabel Behrens, Olga Castaner, Josephine Cruzat, Carolina Delgado, David De Jong-Bambagioni, Claudia Duran-Aniotz and 14 more

Abstract readReview
In one paragraph

Review in Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Scientific knowledge about dementia: From the Global South to the world.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Joaquín MigeotLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile; Global Brain Health Institute (GBHI), Trinity College Dublin (TCD), Dublin, Ireland. Electronic address: joaquin.migeot@gbhi.org.
Daniel Araya-RíosSchool of Medicine, Trinity College Dublin, Chile. Electronic address: arayad@tcd.ie.
Matias MontecinosCenter for Social and Cognitive Neuroscience, Universidad Adolfo Ibáñez, Santiago, Chile.
Sandra BaezGlobal Brain Health Institute (GBHI), Trinity College Dublin (TCD), Dublin, Ireland; Universidad de los Andes, Bogota, Colombia.
María Isabel BehrensCentro de Investigacion Clínica Avanzada (CICA-HCUCH), Chile; Departamento de Neurología y Neurocirugía, Hospital Clínico Universidad de Chile, Av Dr Carlos Lorca Tobar 999, Santiago, Chile; Departamento de Neurociencia, Facultad de Medicina, Universidad de Chile, Independencia, Santiago, Chile; Departamento de Neurología y Psiquiatría, Clínica Alemana-Universidad del Desarrollo, Av Vitacura 5159, Santiago, Chile.
Olga CastanerGlobal Brain Health Institute (GBHI), Trinity College Dublin (TCD), Dublin, Ireland; Hospital del Mar Research Institute, Barcelona, Spain; CIBER de Epidemiologia y salud Pública, Spain.
Josephine CruzatLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile.
Carolina DelgadoDepartamento de Neurociencia, Facultad de Medicina, Universidad de Chile, Santiago, Chile; Departamento de Neurología y Neurocirugía, Hospital Clínico, Unidad de Cerebro Saludable, Universidad de Chile, Santiago, Chile.
David De Jong-BambagioniGlobal Brain Health Institute (GBHI), Trinity College Dublin (TCD), Dublin, Ireland.
Claudia Duran-AniotzLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile.
Dafne Estefania Durón ReyesGlobal Brain Health Institute (GBHI), Trinity College Dublin (TCD), Dublin, Ireland.
Tavia E EvansGlobal Brain Health Institute (GBHI), Trinity College Dublin (TCD), Dublin, Ireland; Department of Genetics, Radboud UMC, Netherlands.
Raul Gonzalez-GomezLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile.
Myriam GutiérrezDepartamento de Neurología y Neurocirugía, Hospital Clínico, Unidad de Cerebro Saludable, Universidad de Chile, Santiago, Chile; Núcleo Magíster en Salud de la Mujer, Universidad Mayor, Santiago, Chile.
Katheen M HaydenGlobal Brain Health Institute (GBHI), Trinity College Dublin (TCD), Dublin, Ireland.
Hernan HernandezLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile.
Agustin IbanezLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile; Global Brain Health Institute (GBHI), Trinity College Dublin (TCD), Dublin, Ireland; Global Brain Health Institute, University of California, San Francisco, CA 94158, USA; Cognitive Neuroscience Center, Universidad de San Andres, Buenos Aires, Argentina.
Agustina LegazLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile; Cognitive Neuroscience Center, Universidad de San Andres, Buenos Aires, Argentina.
Johnny MillerInternational Inequalities Institute, London School of Economics and Political Science, UK.
Sonata MačiulskytėGlobal Brain Health Institute (GBHI), Trinity College Dublin (TCD), Dublin, Ireland; Social Work Department, Klaipeda University, Klaipeda, Lithuania.
Pongpat PutthinunGlobal Brain Health Institute, University of California, San Francisco, CA 94158, USA; Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Hernando Santamaría-GarcíaGlobal Brain Health Institute, University of California, San Francisco, CA 94158, USA; Universidad Javeriana, PhD Program of Neuroscience, Hospital San Ignacio, Bogotá, Colombia; Center for Memory and Cognition Intellectus, Bogotá, Colombia.
Andrea SlachevskyGeroscience Center for Brain Health and Metabolism (GERO), Santiago de Chile, Metropolitan Region of Santiago, 8331150, Chile; Memory and Neuropsychiatric Center (CMYN), Neurology Department, Hospital del Salvador & Faculty of Medicine, University of Chile, Santiago de Chile, Metropolitan Region of Santiago, 7500921, Chile; Neuropsychology and Clinical Neuroscience Laboratory (LANNEC), Physiopathology Program - Institute of Biomedical Sciences (ICBM), Neuroscience and East Neuroscience Departments, Faculty of Medicine, University of Chile, Santiago de Chile, Metropolitan Region of Santiago, 8380453, Chile; Servicio de Neurología, Departamento de Medicina, Clínica Alemana-Universidad del Desarrollo, Santiago de Chile, Metropolitan Region of Santiago, 7550000, Chile.
Dominic TrépelSchool of Medicine, Trinity College Dublin, Chile.

Funding

An automated machine learning approach to language changes in Alzheimer’s disease and frontotemporal dementia across Latino and English-speaking populationsR01AG075775 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI, Adolfo Martin Garcia · 2023 to 2026
$7.2M
US-South American Initiative for Genetic-Neural-Behavioral Interactions in Human Neurodegenerative ResearchR01AG057234 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Claudia Duran-Aniotz, Agustin M. Ibanez · 2019 to 2026
$6.1M
Social epigenetics of Alzheimer's disease and related dementias in Latin American countriesR01AG082056 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI Michael Jay Corley · 2024 to 2026
$3.6M
Circadian Disturbance and Dementia in Latin AmericaR01AG083799 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Kun Hu, Agustin M. Ibanez · 2023 to 2026
$3.0M
NIA NIH HHS R01 AG057234NIA NIH HHS R01 AG075775NIA NIH HHS R01 AG082056NIA NIH HHS R01 AG083799
6 · The paper itself

Abstract

Social determinants of health strongly influence modifiable risk factors for dementia, yet prevention frameworks list only individual-level behaviours and conditions, overlooking the impact of social and environmental factors on the risk of dementia. In this perspective, we introduce the concept of non-monetary costs as a central mechanism through which social determinants shape modifiable risk factors by influencing individuals' ability to adopt healthy behaviours. Drawing from economic theory, we define non-monetary costs as the time and metabolic cost, perceived by individuals as physical and cognitive effort, required to engage in healthy behaviours. Under adverse social determinants of health, individuals effectively lack choice, as the non-monetary costs required to engage in healthy behaviours become prohibitively high. We propose a framework that links social determinants of health adversity to increased dementia risk through non-monetary costs. We apply this framework to each of the fourteen modifiable risk factors for dementia identified by the Lancet Commission, demonstrating how these costs systematically elevate risk in populations facing social adversity. Finally, we explore the implications of incorporating non-monetary cost assessments across research, interventions, clinical care, and public policy. We propose that quantifying and addressing these costs is essential for designing equitable, scalable, and contextually grounded strategies for dementia prevention across socially diverse populations.

Indexed as

Choice BehaviorDementiaSocial Determinants of HealthHumansRisk FactorsDementia preventionInterventionsModifiable risk factorsNon-monetary costsSocial determinants of health

Identifiers

PMID41151667
PMCPMC13034983

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.