Evidence map›Paper›PMID 41151095›Full record

ArticleCancer control : journal of the Moffitt Cancer Center

Development and Validation of a Nomogram Model for Predicting Non-keratinizing Nasopharyngeal Carcinoma by Combining Sex and Three EB Virus Antibodies.

Fu Xu, Yuming Li, Xuanli Zhong, Huafeng Liang, Ruifeng Li, Jun Lyu, Haidi Yang

Abstract readValidation Study
In one paragraph

Article in Cancer control : journal of the Moffitt Cancer Center. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Fu XuDepartment of Otorhinolaryngology Head and Neck Surgery, The Affiliated Shunde Hospital of Jinan University, Foshan, China.ORCID 0000-0002-4816-3330
Yuming LiDepartment of Otorhinolaryngology Head and Neck Surgery, The Affiliated Shunde Hospital of Jinan University, Foshan, China.ORCID 0009-0006-4881-0274
Xuanli ZhongDepartment of Endocrinology and Metabolism, The Affiliated Shunde Hospital of Jinan University, Foshan, China.
Huafeng LiangDepartment of Otorhinolaryngology Head and Neck Surgery, The Affiliated Shunde Hospital of Jinan University, Foshan, China.
Ruifeng LiDepartment of Otorhinolaryngology Head and Neck Surgery, The Affiliated Shunde Hospital of Jinan University, Foshan, China.
Jun LyuDepartment of Clinical Research, The First Affiliated Hospital of Jinan University, Guangzhou, China.ORCID 0000-0002-2237-8771
Haidi YangDepartment of Otolaryngology Head and Neck, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.ORCID 0000-0002-7193-9598

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IntroductionEarly diagnosis of non-keratinizing nasopharyngeal carcinoma (NK-NPC) is a significant clinical challenge. This study assessed combined antibodies and built a nomogram for more accurate NK-NPC screening.MethodsClinical data of 1330 individuals at high risk of nasopharyngeal carcinoma (NPC) from June 2021 to December 2024 were collected retrospectively. They were randomly divided into a training set (n = 930) and a validation set (n = 400) at a ratio of 7:3. The training set was further divided into the NK-NPC group and the non-NK-NPC group. Univariate and multivariate analyses were used to screen for risk factors of cancer, based on which a risk prediction nomogram model was constructed. The predictive performance of the model was evaluated using indicators such as the area under the receiver operating characteristic curve (AUC), integrated discrimination improvement (IDI), decision curve analysis (DCA), and Youden index. Additionally, an external validation set (cases from January-May 2025 at the same hospital) further assessed the model.ResultsSex, EBNA1-IgA, VCA-IgA, and Rta-IgG were independent risk factors for NK-NPC in high-risk populations (

Indexed as

Antibodies, ViralEpstein-Barr Virus InfectionsHerpesvirus 4, HumanNasopharyngeal CarcinomaNasopharyngeal NeoplasmsNomogramsAdultFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsROC CurveSex FactorsAntibodies, Viralantibodiesearly diagnosisEpstein-Barr virusnasopharyngeal carcinomanomogram

Identifiers

PMID41151095
PMCPMC12576163

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.