Evidence map›Paper›PMID 41151042›Full record

ArticleChemistry & biodiversity2026

Osteoprotective Effects and In Silico Profiling of Parinari curatellifolia Planch. Ex Benth. (Chrysobalanaceae) Extract on Acute Plasmodium berghei-Compromised Rat Bone.

Josiane Jouonzo, Raceline Gounoue Kamkumo, Florence Tsofack Ngueguim, Noella Molisa Efange, Sylvestre Saidou Tsila, Bruno Dupon Akamba Ambamba, Judith Laure Ngondi, Lawrence Ayong, Bruno Ndjakou Lenta, Nobert Sewald and 1 more

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In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Josiane JouonzoDepartment of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon.
Raceline Gounoue KamkumoDepartment of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon.
Florence Tsofack NgueguimDepartment of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon.ORCID https://orcid.org/0000-0002-5382-9184
Noella Molisa EfangeDepartment of Biochemistry and Molecular Biology, University of Buea, Buea, Cameroon.
Sylvestre Saidou TsilaDepartment of Organic Chemistry, Higher Teacher Training College, University of Yaoundé I, Yaoundé, Cameroon.
Bruno Dupon Akamba AmbambaDepartment of Biochemistry, Faculty of Science, University of Yaoundé 1, Yaoundé, Cameroon.
Judith Laure NgondiDepartment of Biochemistry, Faculty of Science, University of Yaoundé 1, Yaoundé, Cameroon.
Lawrence AyongCentre Pasteur du Cameroun, Yaoundé, Cameroon.
Bruno Ndjakou LentaDepartment of Organic Chemistry, Higher Teacher Training College, University of Yaoundé I, Yaoundé, Cameroon.
Nobert SewaldDepartment of Organic Chemistry, Faculty of Science, University of Bielefeld, Bielefeld, Germany.
Théophile DimoDepartment of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon.

Funding

Deutscher Akademischer Austauschdienst 57561808
6 · The paper itself

Abstract

Parinari curatellifolia leaves and stem bark are traditionally used, to treat both malaria and bone disorders. This work aimed at investigating the osteoformative effects of the P. curatellifolia aqueous leaves and bark mixture extract on malaria-induced bone alterations. The in vitro antiplasmodial activity of the extract was assessed on Plasmodium falciparum 3D7 and Dd2. The phytochemical characterization of the extract and its fractions was carried out using LC-MS technique. The in vivo study was evaluated using Plasmodium berghei ANKA-induced malaria and bone disorders. Parasitemia was monitored, and hematological, biochemical, immunological, and histopathological parameters were assessed. The docking study was performed on Pf20S, TyrRS, MyD88, and RANKL using the Molecular Operating Environment 14. The extract exhibited in vitro antiplasmodial activity on P. falciparum 3D7 and Dd2 strains. The LC-MS analysis of the extract and fractions revealed several peaks, of which 12 were characterized. The extract reduced parasitemia (p < 0.001), improved hematological parameters, corrected malaria-induced bone damage by increasing (p < 0.001) bone osteocalcin, TGF-β1, ALP activity, mineralization, as well as reversing Plasmodium-induced inflammation. Likewise, the identified compounds exhibited strong inhibitory binding potential. These findings support the ability of the extract to correct malaria-related bone disorders by acting as an antiplasmodial, osteoprotective, anti-inflammatory, and antioxidant agent.

Indexed as

AntimalarialsBone and BonesMalariaPlant ExtractsPlasmodium bergheiAnimalsMaleMolecular Docking SimulationParasitic Sensitivity TestsPlant LeavesPlasmodium falciparumRatsRats, WistarAntimalarialsPlant Extractsbone disorderscytokinesmalariamolecular dockingParinari curatellifolia

Identifiers

PMID41151042
PMCPMC13421871

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.