Evidence map›Paper›PMID 41151017›Full record

ArticleACS chemical biology2025

Exploring Metalloproteome Remodeling in Calprotectin-Stressed

Maximillian K Osterberg, Daniel W Bak, Claudia Andreini, Minyong Kim, Jeanette M Critchlow, Jonathan C Trinidad, Peter V Cornish, Tae Akizuki, Walter J Chazin, Eric P Skaar and 2 more

Abstract read
In one paragraph

Article in ACS chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Maximillian K OsterbergDepartment of Chemistry, Indiana University, Bloomington, Indiana 47405-7102, United States.
Daniel W BakDepartment of Chemistry, Boston College, Chestnut Hill, Massachusetts 02467-3860, United States.ORCID 0000-0002-2252-1718
Claudia AndreiniMagnetic Resonance Centre (CERM), University of Florence, Florence, Sesto Fiorentino 50019, Italy.
Minyong KimDepartment of Chemistry, Indiana University, Bloomington, Indiana 47405-7102, United States.
Jeanette M CritchlowDepartment of Pathology, Microbiology, and Immunology, and Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.
Jonathan C TrinidadLaboratory for Biological Mass Spectrometry, Department of Chemistry, Indiana University, Bloomington, Indiana 47405-7102, United States.
Peter V CornishDepartment of Biochemistry, University of Missouri, Columbia, Missouri 65211, United States.ORCID 0000-0003-0574-0748
Tae AkizukiDepartments of Biochemistry and of Chemistry, and Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37240, United States.
Walter J ChazinDepartments of Biochemistry and of Chemistry, and Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37240, United States.
Eric P SkaarDepartment of Pathology, Microbiology, and Immunology, and Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.ORCID 0000-0001-5094-8105
Eranthie WeerapanaDepartment of Chemistry, Boston College, Chestnut Hill, Massachusetts 02467-3860, United States.ORCID 0000-0002-0835-8301
David P GiedrocDepartment of Chemistry, Indiana University, Bloomington, Indiana 47405-7102, United States.ORCID 0000-0002-2342-1620

Funding

Host-mediated zinc sequestration during Acinetobacter baumannii infectionR01AI101171 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WALTER J. CHAZIN, DAVID P. GIEDROC · 2013 to 2026
$8.2M
Neisseria gonorrhoeae metal transporters that subvert nutritional immunityR01AI127793 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI CYNTHIA N CORNELISSEN, Alison K Criss · 2017 to 2026
$6.8M
Transition Metal Homeostasis and Reactive Sulfur Species in Bacterial PathogensR35GM118157 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI DAVID P. GIEDROC · 2016 to 2026
$5.9M
Developing chemical-proteomic tools to investigate cysteine oxidationR35GM134964 · NIGMS · BOSTON COLLEGE · PI WEERAPANA, ERANTHIE · 2020 to 2024
$3.1M
Graduate Training Program in Quantitative and Chemical Biology at Indiana University BloomingtonT32GM131994 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI JARED C LEWIS · 2019 to 2026
$2.4M
National Science Foundation MCA 2122902NIAID NIH HHS R01 AI101171NIAID NIH HHS R01 AI127793NIGMS NIH HHS R35 GM118157NIGMS NIH HHS R35 GM134964NIGMS NIH HHS T32 GM131994
6 · The paper itself

Abstract

The growth of bacterial pathogens is limited by nutritional immunity, where the infected host deploys transition metal scavenging proteins including calprotectin (CP) to starve the bacterium of essential transition metals. Prior work reveals that CP induces a significant Zn- and Fe-starvation response in the Gram-negative opportunistic pathogen

Indexed as

Acinetobacter baumanniiBacterial ProteinsLeukocyte L1 Antigen ComplexMetalloproteinsProteomicsIronProteomeStress, PhysiologicalZincBacterial ProteinsIronLeukocyte L1 Antigen ComplexMetalloproteinsProteomeZinc

Identifiers

PMID41151017
PMCPMC12797879

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.