ArticleJournal of the American Chemical Society2025
One-Electron Approach for Trans-Selective Alkyne Semi-Reduction via Cobalt Catalysis.
Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Electrochemical Hydrogenation of Aza-Arenes Using HJournal of the American Chemical Society · 2026Article
- Electrochemical reduction of unsaturated carbon-carbon bonds via 3d transition-metal catalysis.Beilstein journal of organic chemistry · 2026Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The diastereoselective semireduction of alkynes to alkenes is a powerful transformation in synthetic chemistry, yet catalytic methods for trans-selective (E) alkyne reduction remain limited. Herein, we introduce a fundamentally new approach for the highly selective trans-semireduction of internal alkynes, enabled by a cobalt-catalyzed electrochemical radical pathway. This method offers a broad substrate scope, accommodating alkynes with diverse electronic and steric profiles, and displays exceptional chemoselectivity and functional group tolerance. The methodology was extended to isotopically labeled trans-deuteration and demonstrated excellent chemoselectivity in substrates containing multiple alkyne motifs. Mechanistic studies, including cyclic voltammetry, UV-vis spectroelectrochemistry, and DFT calculations, support a dual catalytic cycle involving electrochemical Co-H formation and a subsequent organometallic radical pathway. Insights from this mechanism guided the development of a complementary chemical oxidative protocol, enabling access to
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Registered trials
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