Evidence map›Paper›PMID 41150904›Full record

ArticleAnnals of clinical and translational neurology2026

Accelerated Progression of Gait Impairment in Parkinson's Disease and REM Sleep Without Atonia.

Sommer L Amundsen-Huffmaster, Jae Woo Chung, Maria E Linn-Evans, Matthew N Petrucci, Chiahao Lu, Destiny J Weaver, Joshua De Kam, Scott E Cooper, Paul J Tuite, Aleksandar Videnovic and 2 more

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Article in Annals of clinical and translational neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sommer L Amundsen-HuffmasterDepartment of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0001-8079-328X
Jae Woo ChungDepartment of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0002-9107-9038
Maria E Linn-EvansDepartment of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0002-8535-2894
Matthew N PetrucciDepartment of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0003-3353-2532
Chiahao LuDepartment of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0002-6356-7253
Destiny J WeaverDepartment of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0001-9193-1561
Joshua De KamDepartment of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0009-0008-1060-180X
Scott E CooperDepartment of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0003-4263-9593
Paul J TuiteDepartment of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0003-1413-7924
Aleksandar VidenovicDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-9237-1516
Michael J HowellDepartment of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0001-7535-0724
Colum D MacKinnonDepartment of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0002-2722-7868

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
Understanding Circuit Dynamics in Parkinson's Disease using Real-Time Neural ControlP50NS123109 · NINDS · UNIVERSITY OF MINNESOTA · PI VITEK, JERROLD L · 2021 to 2025
$11.3M
Pathophysiology-based approaches to deep brain stimulation for Parkinson's diseaseP50NS098573 · NINDS · UNIVERSITY OF MINNESOTA · PI EBERLY, LYNN E · 2016 to 2020
$9.1M
PREDOCTORAL TRAINING OF NEUROSCIENTISTST32GM008471 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI EBNER, TIMOTHY J · 1993 to 2017
$4.9M
Targeted Pathway Activation for PosturalInstability and Gait Disorder in Parkinson'sDiseaseR01NS124814 · NINDS · UNIVERSITY OF MINNESOTA · PI SCOTT E COOPER · 2022 to 2026
$3.7M
Corticosubthalamic Plasticity in the Parkinsonian StateR01NS113746 · NINDS · EMORY UNIVERSITY · PI HAREL, NOAM, MACKINNON, COLUM D · 2019 to 2023
$3.5M
Neuroplasticity and the emergence of motor and cognitive deficits in prodromal synucleinopathyRF1NS126609 · NINDS · UNIVERSITY OF MINNESOTA · PI MACKINNON, COLUM D · 2022 to 2022
$2.3M
Predictors of progression to freezing of gait in Parkinson's diseaseR01NS088679 · NINDS · UNIVERSITY OF MINNESOTA · PI MACKINNON, COLUM D · 2015 to 2018
$1.6M
Mechanisms of Movement Facilitation and Release by Cueing in Parkinson's diseaseR01NS070264 · NINDS · UNIVERSITY OF MINNESOTA · PI MACKINNON, COLUM D · 2011 to 2013
$866k
Circadian Rhythms Regulation in Pre-Manifest SynucleinopathiesR21NS108022 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI VIDENOVIC, ALEKSANDAR · 2018 to 2019
$463k
MnDRIVE FellowshipNational Science Foundation NRT Fellowship DGE-1734815NCATS NIH HHS UL1TR000114NINDS NIH HHS P50 NS09857NINDS NIH HHS P50 NS098573NINDS NIH HHS P50 NS123109NINDS NIH HHS R01 NS070264NINDS NIH HHS R01 NS088679NINDS NIH HHS R01 NS113746NINDS NIH HHS R01 NS124814NINDS NIH HHS R21 NS108022NINDS NIH HHS Research Supplement NS113746, D.J.WNINDS NIH HHS RF1 NS126609NINDS NIH HHS T32GM008471Parkinson's FoundationParkinson Study GroupWallin Neuroscience Discovery Fund
6 · The paper itself

Abstract

objectivePeople with Parkinson's disease (PD) and rapid eye movement (REM) sleep without atonia (RSWA) often have more severe gait disturbances compared to PD without RSWA. The association between the presence and expression of RSWA and the rate of progression of gait impairment in PD is unknown. This study examined the changes in spatiotemporal gait metrics over 3 years in people with mild-to-moderate PD (median 1.5 years since diagnosis at baseline) with (PD+RSWA, n = 16) and without RSWA (PD-RSWA, n = 14), and matched controls (n = 16).

methodsSteady-state gait metrics were obtained using a pressure-sensitive walkway at baseline and 3-year follow-up. RSWA scores were measured from electromyographic recordings during video-based polysomnography at baseline. Linear mixed models tested for the effects of visit, group, side (less vs. more affected), and their interactions. In people with PD, Spearman's correlations examined the relationship between baseline RSWA scores and the change in gait metrics.

resultsStride velocity variability was larger in PD+RSWA, compared to PD-RSWA and controls. Spatial and temporal measures of gait significantly worsened in both PD groups over 3 years. The PD+RSWA group showed a significantly larger decrement in step length (p < 0.05; mean = 7.9%) compared to PD-RSWA (2.6%) and controls (2.3%). Variability measures did not change significantly. In PD, the change in stride length correlated with chin RSWA scores at baseline.

interpretationRWSA in early PD may be a harbinger of a more rapid progression in gait impairment, characterized primarily by a shortening of steps.

Indexed as

Disease ProgressionGait Disorders, NeurologicParkinson DiseaseSleep, REMAgedElectromyographyFemaleHumansMaleMiddle AgedPolysomnographydisease progressiongaitParkinson's diseaseprospective studyREM sleep without atonia

Identifiers

PMID41150904
PMCPMC12968468

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.