ArticleCell reports2025
Maternal undernutrition exacerbates microbiota-driven growth stunting through pre- and postnatal effects.
Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Determinants of stunting among Indonesian children: a cross-sectional study on the role of child, maternal, and vaccination factors.BMC pregnancy and childbirth · 2026Article
- Disrupting the vicious cycle of malnutrition and enteropathy: advancing strategies to improve child physical and neurocognitive outcomes.Frontiers in public health · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Linear growth stunting due to undernutrition affects 20% of children under the age of 5, with far-reaching consequences, including increased susceptibility to infection and altered cognitive development. Current nutritional interventions are largely ineffective in rescuing linear growth. A significant proportion of stunting originates in utero; however, the mechanisms by which maternal undernutrition is transmitted between generations remain poorly characterized. Here, we employ a gnotobiotic murine model of intergenerational undernutrition in which offspring are exposed to distinct microbial communities both in utero and after birth. We find that maternal undernutrition exacerbates offspring growth deficits in a microbiota-dependent manner. Maternal undernutrition also alters the offspring microbiome, increasing the abundance of Enterococcus species and Escherichia coli. Cross-fostering demonstrates critical roles for the microbiota in growth during both gestation and early life. These findings emphasize the need to target both mother and child in the design of nutritional therapies for undernutrition.
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What OpenQuestion holds
Registered trials
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