ArticleCurrent issues in molecular biology2025
Assessment of Cervical IL-6 Levels and Neonatal Inflammatory Response in Preterm Birth Following Preterm Premature Rupture of Membranes.
Article in Current issues in molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Mechanisms of vaginal bacteria-induced fetal membrane damage and tocilizumab's therapeutic potential in PPROM.BMC pregnancy and childbirth · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundPreterm premature rupture of membranes (PPROM) is a leading cause of preterm delivery, occurring in 40-50% of cases, with a 3-4% overall incidence. During expectant management, chorioamnionitis is typically monitored using serum inflammatory markers (e.g., leukocyte count, CRP), though cervical interleukin-6 (IL-6) has emerged as a promising local marker. This study investigated the correlation between cervical IL-6 and maternal and neonatal inflammatory parameters.
methodsThis prospective non-randomized clinical trial was performed with 51 patients with expectantly managed PPROM. Samples were obtained twice a week using cervical swabs placed into a stabilizer solution. Cervical IL-6 levels were measured by routine automated chemiluminescence immunoassay, with reference to albumin levels. Maternal serum C-reactive protein (CRP) levels and leukocyte counts and neonatal serum CRP and procalcitonin (PCT) levels were also determined. Spearman correlations of the IL-6 level with other markers and clinicopathological parameters were examined.
resultsCervical IL-6 levels correlated more strongly with neonatal CRP and PCT levels on the first day after delivery than with maternal serum markers while showing no significant association with the PPROM-to-delivery interval.
conclusionCervical IL-6 level determination may help to inform the timing of labor induction in cases of PPROM, with consideration of the maternal and neonatal conditions. We believe that the monitoring of the cervical IL-6 level could enable good prediction of perinatal inflammation, although more data are needed to support this hypothesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.