Evidence map›Paper›PMID 41150725›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Monocyte-derived exosomal periostin driven by histone lactylation contributes to retinal neovascularization.

Wei Shen, Zheng Nie, Mengzhu Wang, Haorui Zhang, Yongxuan Liu, Huimin Zhu, Wen Zhou, Lin Zhang, Min Zhao, Hao Zeng and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Scleral Postn Drives Myopia via Promoting Myofibroblast Transdifferentiation.Investigative ophthalmology & visual science · 2026
    Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Wei Shen *Department of Ophthalmology, Shanghai Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Zheng Nie *Department of Ophthalmology, Shanghai Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Mengzhu Wang *Department of Ophthalmology, Shanghai Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Haorui Zhang *Department of Ophthalmology, Shanghai Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Yongxuan LiuDepartment of Ophthalmology, Shanghai Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Huimin ZhuDepartment of Ophthalmology, Shanghai Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Wen ZhouDepartment of Ophthalmology, Shanghai Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Lin ZhangDepartment of Ophthalmology, Shanghai Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Min ZhaoDepartment of Ophthalmology, Shanghai Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Hao ZengDepartment of Ophthalmology, Shanghai Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Mai PengDepartment of Ophthalmology, Shanghai Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Yukun ZhouDepartment of Ophthalmology, Shanghai Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Jiawei ZhaoDepartment of Ophthalmology, Shanghai Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Shikun WangDepartment of Ophthalmology, Shanghai Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Guangping GaoDepartment of Ophthalmology, Shanghai Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Yuxin JiangDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
Wenbin ZouDepartment of Gastroenterology, Shanghai Institute of Pancreatic Diseases, Shanghai Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Xi ShenDepartment of Ophthalmology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Liqiang WangDepartment of Ophthalmology, The Third Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100089, China.
Hongyuan SongDepartment of Ophthalmology, Shanghai Changhai Hospital, Naval Medical University, Shanghai 200433, China.ORCID 0000-0001-8187-2799

Funding

MOST | National Key Research and Development Program of China Stem Cell and Translational Research (Stem Cell and Translational Research) 2022YFA1105500MOST | National Natural Science Foundation of China (NSFC) 82171081MOST | National Natural Science Foundation of China (NSFC) 82271106
6 · The paper itself

Abstract

Exosomes are signaling messengers facilitating intercellular communication by delivering molecular cargo. Here, we observed increased levels of exosomal periostin (POSTN) in the blood plasma of patients with proliferative diabetic retinopathy (PDR). Monocytes contributed to elevated levels of exosomal POSTN, and deletion of

Indexed as

Cell Adhesion MoleculesExosomesHistonesMonocytesRetinal NeovascularizationAnimalsDiabetic RetinopathyFemaleGlycolysisHexokinaseHumansHypoxia-Inducible Factor 1, alpha SubunitMaleMiceMice, KnockoutPeriostinCell Adhesion MoleculesHexokinaseHistonesHK2 protein, humanHypoxia-Inducible Factor 1, alpha SubunitPeriostinPOSTN protein, humandiabetesextracellular vesicleslactylationmetforminretinal neovascularization

Identifiers

PMID41150725
PMCPMC12595469

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.