Evidence map›Paper›PMID 41150715›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Modulating the microbiome as an approach to anticancer drug development.

Jemma Arakelyan, Ho-Jung Choe, Chengnan Wu, Daniil A Rusanov, Elena E Bardina, Anna A Kirsanova, Yuliya V Zakalyukina, Nikita Y Shmelev, Anton P Tyurin, Vladislav Y Komarov and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Jemma Arakelyan *Department of Chemistry, Drug Discovery Lab, City University of Hong Kong, Hong Kong Special Administrative Region 999077, People's Republic of China.
Ho-Jung Choe *Department of Chemistry, Drug Discovery Lab, City University of Hong Kong, Hong Kong Special Administrative Region 999077, People's Republic of China.
Chengnan Wu *Department of Chemistry, Drug Discovery Lab, City University of Hong Kong, Hong Kong Special Administrative Region 999077, People's Republic of China.ORCID 0000-0002-0740-7546
Daniil A Rusanov *Department of Chemistry, Drug Discovery Lab, City University of Hong Kong, Hong Kong Special Administrative Region 999077, People's Republic of China.ORCID 0000-0002-7573-3730
Elena E BardinaA.V. Nikolaev Institute of Inorganic Chemistry, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russian Federation.
Anna A KirsanovaDepartment of Chemistry, Drug Discovery Lab, City University of Hong Kong, Hong Kong Special Administrative Region 999077, People's Republic of China.ORCID 0000-0003-2728-3525
Yuliya V ZakalyukinaDepartment of Soil Science, Lomonosov Moscow State University, Moscow 119991, Russian Federation.ORCID 0000-0001-8943-5761
Nikita Y ShmelevA.V. Nikolaev Institute of Inorganic Chemistry, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russian Federation.
Anton P TyurinShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117997, Russian Federation.ORCID 0000-0002-5597-6161
Vladislav Y KomarovA.V. Nikolaev Institute of Inorganic Chemistry, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russian Federation.ORCID 0000-0001-7519-1719
Vladimir KushnarevDepartment of Chemistry, Drug Discovery Lab, City University of Hong Kong, Hong Kong Special Administrative Region 999077, People's Republic of China.
Nikolay S KarnaukhovMoscow Clinical Research Center named after A.S. Loginov, Moscow 111123, Russian Federation.
Gerald D'CruzDepartment of Chemistry, Drug Discovery Lab, City University of Hong Kong, Hong Kong Special Administrative Region 999077, People's Republic of China.
Eugene S VasilyevN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russian Federation.ORCID 0000-0001-7476-3826
Eunice DotseDepartment of Biomedical Sciences, City University of Hong Kong, Hong Kong Special Administrative Region 999077, People's Republic of China.ORCID 0000-0002-1118-6942
Kwan T ChowDepartment of Biomedical Sciences, City University of Hong Kong, Hong Kong Special Administrative Region 999077, People's Republic of China.ORCID 0000-0003-1012-0797
William C ChoDepartment of Clinical Oncology, Queen Elizabeth Hospital, Kowloon 999077, Hong Kong.ORCID 0000-0003-4174-4586
Alexey V TkachevN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russian Federation.
Artem L GushchinA.V. Nikolaev Institute of Inorganic Chemistry, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russian Federation.
Maria V BabakDepartment of Chemistry, Drug Discovery Lab, City University of Hong Kong, Hong Kong Special Administrative Region 999077, People's Republic of China.ORCID 0000-0002-2009-7837

Funding

Croucher Foundation 9500032Croucher Foundation 9509002Hong Kong Research Grants Council 11103523Hong Kong Research Grants Council C7008-22GPneumoconiosis Compensation Fund Board of Hong Kong 9211315Russian Science Foundation (RSF) 21-13-00092Russian Science Foundation (RSF) 23-73-10157the Ministry of Science and Higher Education of the Russian Federation 121031700313-8the Ministry of Science and Higher Education of the Russian Federation 121031700315-2
6 · The paper itself

Abstract

Recent studies have suggested that the commensal microbiome positively affects cancer prognosis and treatment outcomes. However, only a few strategies for regulating the microbiome composition have been reported. In this study, we identified gold(I) complexes that selectively inhibited nonbeneficial bacterial strains in vitro without affecting commensal

Indexed as

Antineoplastic AgentsDrug DevelopmentGastrointestinal MicrobiomeMicrobiotaNeoplasmsAnimalsCell Line, TumorFemaleHumansMiceAntineoplastic Agentsanticancer therapeuticsbioinorganicgold complexmicrobiometumor microenvironment

Identifiers

PMID41150715
PMCPMC12595427

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.