Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
15 authors.
Ryan M MarquardtReproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.ORCID 0000-0002-6597-4506
Sara A GrimmBiostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.ORCID 0000-0003-3050-1909
San-Pin WuReproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.ORCID 0000-0001-9626-784X
Peter F LaisReproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
Shu-Yun LiReproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
Xin XuEpigenetics and RNA Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
Erin SmithbergerEpigenetics and RNA Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
David CunefareComparative and Molecular Pathogenesis Branch, Division of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
Charan GantaComparative and Molecular Pathogenesis Branch, Division of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
David OlsonCharles River Laboratories, Wilmington, MA 01887.
Eunhee M JeongDepartment of Obstetrics, Gynecology and Women's Health, University of Missouri, Columbia, MO 65212.ORCID 0009-0008-0335-5364
Jae-Wook JeongDepartment of Obstetrics, Gynecology and Women's Health, University of Missouri, Columbia, MO 65212.
Bruce A LesseyDepartment of Obstetrics and Gynecology, Wake Forest Baptist Health, Winston-Salem, NC 27101.ORCID 0000-0002-8451-2817
John P LydonDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0001-6472-636X
Francesco J DeMayoReproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.ORCID 0000-0002-9480-7336
Funding
Animal Research SupportZIGES102585 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI COBLE, DONDRAE · 2009 to 2025
$98.6M
Program in Clinical Research, Clinical Support Services and Clinical TrainingZIDES102465 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI KIRSCHNER, LAWRENCE · 2009 to 2025
$84.7M
Epigenomics and DNA SequencingZICES102545 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WADE, PAUL A · 2012 to 2025
$27.4M
Pathology Services Supporting the Division Translational ToxicologyZICES103376 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI CESTA, MARK · 2022 to 2025
$23.9M
Integrative BioinformaticsZICES103371 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LI, JIAN-LIANG · 2022 to 2025
$11.5M
Molecular Analysis of Uterine ReceptivityR01HD042311 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI LYDON, JOHN P · 2009 to 2023
$4.8M
CRR LIGAND ASSAY AND ANALYSIS CORER24HD102061 · NICHD · UNIVERSITY OF VIRGINIA · PI HAISENLEDER, DANIEL J. · 2019 to 2023
$2.2M
The Role of SRF in Uterine HomeostasisFI2GM154603 · NIGMS · U.S. NATIONAL INST OF ENVIRON HLTH SCIS · PI MARQUARDT, RYAN · 2024 to 2024
–
HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R01HD042311HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R24HD102061HHS | NIH | National Institute of Environmental Health Sciences (DEHS) 1Z1AES103311HHS | NIH | National Institute of Environmental Health Sciences (DEHS) 1ZICES102545-17HHS | NIH | National Institute of Environmental Health Sciences (DEHS) 1ZICES103371HHS | NIH | National Institute of Environmental Health Sciences (DEHS) 1ZICES103376-03HHS | NIH | National Institute of Environmental Health Sciences (DEHS) 1ZIDES102465HHS | NIH | National Institute of Environmental Health Sciences (DEHS) 1ZIGES102585-16HHS | NIH | National Institute of General Medical Sciences (NIGMS) FI2GM154603Intramural NIH HHS ZIC ES102545Intramural NIH HHS ZIC ES103371Intramural NIH HHS ZIC ES103376Intramural NIH HHS ZID ES102465Intramural NIH HHS ZIG ES102585Lalor Foundation (The Lalor Foundation) Serum Response Factor as a Progesterone Receptor Coregulator in Uterine Function and FertilityNICHD NIH HHS R01 HD042311NICHD NIH HHS R24 HD102061NIGMS NIH HHS FI2 GM154603
6 · The paper itself
Abstract
Pregnancy requires a supportive uterine environment facilitated by steroid hormone-regulated differentiation of endometrial stromal fibroblasts into decidual cells and tight control of inflammation. Serum response factor (SRF) is a widely expressed transcription factor essential for mesenchymal cell growth and differentiation with noted roles in hormonal regulation of muscle tissues but little characterization in reproductive organs. Here, we reveal that endometrial SRF is dysregulated in human endometriosis and is critical for female reproductive success in mice through regulation of endometrial stromal and epithelial cells. Immunohistochemical analysis identified decreased endometrial SRF expression in infertile endometriosis patient tissues. RNAi-based
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Serum response factor is essential for endometrial function and prevention of inflammatory fibrosis. · full record | OpenQuestion