Evidence map›Paper›PMID 41150586›Full record

ArticleToxics2025

Genetic Damage to Human Lymphocytes Induced by Contaminated Water in Populations Surrounding Lake Chapala and the Santiago River, Jalisco, México.

Mónica Reynoso-Silva, Carlos Alvarez-Moya, Fernando Manuel Guzmán-Rubio, Daniela Guadalupe Velázquez-Cruz, Daniel Moreno-Del Río, Blanca Catalina Ramírez-Hernández, Lucía Barrientos-Ramírez, José de Jesús Vargas-Radillo, Paulina Beatriz Gutiérrez-Martínez, Mario Alberto Ruíz-López

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mónica Reynoso-SilvaEnvironmental Mutagénesis Laboratory, Cellular and Molecular Department, University of Guadalajara, Guadalajara 45200, Mexico.ORCID 0000-0002-8866-8990
Carlos Alvarez-MoyaEnvironmental Mutagénesis Laboratory, Cellular and Molecular Department, University of Guadalajara, Guadalajara 45200, Mexico.ORCID 0000-0003-4099-6845
Fernando Manuel Guzmán-RubioEnvironmental Mutagénesis Laboratory, Cellular and Molecular Department, University of Guadalajara, Guadalajara 45200, Mexico.
Daniela Guadalupe Velázquez-CruzEnvironmental Mutagénesis Laboratory, Cellular and Molecular Department, University of Guadalajara, Guadalajara 45200, Mexico.
Daniel Moreno-Del RíoEnvironmental Mutagénesis Laboratory, Cellular and Molecular Department, University of Guadalajara, Guadalajara 45200, Mexico.
Blanca Catalina Ramírez-HernándezApplied Ecology Department, University of Guadalajara, Guadalajara 45200, Mexico.ORCID 0000-0002-0576-8997
Lucía Barrientos-RamírezDepartment of Wood, Cellulose and Paper, University of Guadalajara, CUCEI, Road Ing Ramón Padilla Sánchez 2100, Las Agujas, Zapopan 44600, Mexico.ORCID 0000-0003-4451-8410
José de Jesús Vargas-RadilloDepartment of Wood, Cellulose and Paper, University of Guadalajara, CUCEI, Road Ing Ramón Padilla Sánchez 2100, Las Agujas, Zapopan 44600, Mexico.ORCID 0000-0002-1638-469X
Paulina Beatriz Gutiérrez-MartínezDepartment of Environmental Sciences, University of Guadalajara, Guadalajara 45200, Mexico.ORCID 0000-0002-3684-0576
Mario Alberto Ruíz-LópezDepartment of Botany and Zoology, University of Guadalajara, Nextipac, Zapopan 45510, Mexico.ORCID 0000-0001-8413-5663

Funding

Guadalajara University Departamental sopourt p3e 2025 BCyM/354/2024
6 · The paper itself

Abstract

Polluted water in the Chapala-Santiago basin (CSB) contains several genotoxic substances that present risks to human health, particularly among residents of communities surrounding Lake Chapala and the Santiago River, where a high prevalence of cancer has been documented. For this reason, it is necessary to study the genotoxic activity of these waters and the genetic damage in inhabitants of the surrounding populations. This study assessed the genotoxicity of water in various communities in the CSB and evaluated DNA damage to lymphocytes in residents of nearby locations. The alkaline comet assay was employed to evaluate water genotoxicity and DNA damage to lymphocytes in residents living near these waters. A standardized questionnaire was distributed to participants of this study to evaluate their exposure to polluted water. Significant genotoxic activity (

Indexed as

carcinogenicitycomet assayDNA damagegenotoxicitypollution

Identifiers

PMID41150586
PMCPMC12568238

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.