Evidence map›Paper›PMID 41150543›Full record

ArticleToxics2025

Strain and Sex Variability in Liver, Kidney and Lung Levels of DNA Adducts EB-GII and

Erik Moran, Samantha Goodman, Fred A Wright, Richard Evans, Natalia Y Tretyakova, Ivan Rusyn

Abstract read
In one paragraph

Article in Toxics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Erik MoranDepartment of Medicinal Chemistry and Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0009-0007-2439-674X
Samantha GoodmanDepartment of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0003-4828-0964
Fred A WrightBioinformatics Research Center and Departments of Biological Sciences and Statistics, North Carolina State University, Raleigh, NC 27695, USA.
Richard EvansDepartment of Medicinal Chemistry and Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.
Natalia Y TretyakovaDepartment of Medicinal Chemistry and Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-0621-6860
Ivan RusynDepartment of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA.

Funding

Untargeted Adductomics to Characterize Ethnic Differences in the Exposome of SmokersP01CA138338 · NCI · UNIVERSITY OF MINNESOTA · PI Daniel O Stram · 2010 to 2026
$33.4M
Regulatory Science in Environmental Health and ToxicologyT32ES026568 · NIEHS · TEXAS A&M UNIVERSITY · PI Weihsueh A Chiu, Natalie M Johnson · 2016 to 2026
$3.8M
Chromatin regions, genes and pathways that confer susceptibility to chemical-induced DNA damageR01ES029911 · NIEHS · TEXAS A&M AGRILIFE RESEARCH · PI RUSYN, IVAN, THREADGILL, DAVID W. · 2019 to 2023
$3.3M
Characterizing Gene-Environment Interactions that Affect Individual Susceptibility to an Expanding Chemical ExposomeR01ES033243 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Fred A. Wright · 2022 to 2026
$2.1M
NCI NIH HHS P01 CA138338NIEHS NIH HHS R01 ES029911NIEHS NIH HHS R01 ES033243NIEHS NIH HHS T32 ES026568NIH HHS 1P01CA138338-05NIH HHS 1R01ES029911-05NIH HHS 1T32ES026568-05
6 · The paper itself

Abstract

1,3-butadiene (BD) is a volatile organic pollutant. Upon inhalation, it is metabolically activated to reactive epoxides which alkylate genomic DNA and form potentially mutagenic monoadducts and DNA-DNA crosslinks including N7-(1-hydroxyl-3-buten-1-yl)guanine (EB-GII) and 1,4-

Indexed as

1,3-butadieneDNA adductsintra-species variabilitymouse model

Identifiers

PMID41150543
PMCPMC12568132

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.