Evidence map›Paper›PMID 41150534›Full record

ReviewToxics2025

Association of Bisphenol Exposure and Serum Hypothalamic-Pituitary-Thyroid Axis Hormone Levels in Adults and Pregnant Women: A Systematic Review and Meta-Analysis.

Mazhar Sultan, Xuan Ma, Qiurun Yu, Francis Manyori Bigambo, Yufeng Tang, Natasha Chitakwa, Farah Kafauit, Qinrou Chen, Quanquan Guan, Yankai Xia

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Toxics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mazhar SultanState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China.ORCID 0009-0006-5722-9107
Xuan MaThe Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and Prevention, Wuxi Medical Center, Nanjing Medical University, Nanjing 210000, China.
Qiurun YuState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
Francis Manyori BigamboChildren's Hospital of Nanjing Medical University, Nanjing 211166, China.
Yufeng TangDepartment of Policy and Public Management, Zanvyl Krieger School of Arts and Sciences, Johns Hopkins University, Washington, DC 20001, USA.
Natasha ChitakwaState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
Farah KafauitDepartment of Clinical Pharmacology, Sir Run Run Hospital, Nanjing Medical University, Nanjing 211166, China.
Qinrou ChenState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
Quanquan GuanState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China.ORCID 0000-0003-1658-9983
Yankai XiaState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China.ORCID 0000-0003-0484-4035

Funding

Joint Funds of the National Natural Science Foundation of China U22A20407National Natural Science Foundation of China 82304093
6 · The paper itself

Abstract

backgroundBisphenols (BPs) are present in medical instruments, plastic containers, and personal care products (PCPs). Bisphenol A has been replaced by its alternatives, bisphenol S, F, AF, and B. Due to the awareness of their toxicity, mixed exposure to these alternatives at the regional level has been given less attention; there is a need to study this area of research. This meta-analysis examined the exposure of urinary bisphenol A and its metabolites to blood Hypothalamic-Pituitary-Thyroid axis hormones (HPT axis hormones) in pregnant women and adult males and females. We searched Embase, PubMed, Web of Science, Cochrane Library, and CINAHL until 8 January 2025, yielding 4588 articles using the PECO framework. Quality assessment was done using AHRQ: Agency for Healthcare Research and Quality for cross-sectional and NOS: Newcastle Ottawa Scale for cohort studies, with combined exposure evaluated using random and fixed-effect models. The

Indexed as

adultsbisphenolsmeta-analysispregnant womanthyroid hormones

Identifiers

PMID41150534
PMCPMC12568303

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.