Evidence map›Paper›PMID 41150527›Full record

ArticleToxics2025

Construction of a Novel 3D Urinary Bladder Mucosa Model and Its Application in Toxicity Assessment of Arsenicals.

Runjie Guo, Min Gi, Tohru Kiyono, Arpamas Vachiraarunwong, Shugo Suzuki, Masaki Fujioka, Guiyu Qiu, Kwanchanok Praseatsook, Yurina Kawamura, Anna Kakehashi and 3 more

Abstract read
In one paragraph

Article in Toxics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Runjie GuoDepartment of Environmental Risk Assessment, Osaka Metropolitan University Graduate School of Medicine, Osaka 554-8585, Japan.
Min GiDepartment of Environmental Risk Assessment, Osaka Metropolitan University Graduate School of Medicine, Osaka 554-8585, Japan.ORCID 0000-0003-1642-8127
Tohru KiyonoProject for Prevention of HPV-Related Cancer, Division of Collaborative Research and Development, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa 277-8577, Japan.ORCID 0000-0003-1769-403X
Arpamas VachiraarunwongDepartment of Environmental Risk Assessment, Osaka Metropolitan University Graduate School of Medicine, Osaka 554-8585, Japan.ORCID 0000-0002-0463-2289
Shugo SuzukiDepartment of Molecular Pathology, Osaka Metropolitan University Graduate School of Medicine, Osaka 554-8585, Japan.
Masaki FujiokaDepartment of Molecular Pathology, Osaka Metropolitan University Graduate School of Medicine, Osaka 554-8585, Japan.
Guiyu QiuDepartment of Environmental Risk Assessment, Osaka Metropolitan University Graduate School of Medicine, Osaka 554-8585, Japan.
Kwanchanok PraseatsookDepartment of Environmental Risk Assessment, Osaka Metropolitan University Graduate School of Medicine, Osaka 554-8585, Japan.ORCID 0000-0001-9274-2869
Yurina KawamuraDepartment of Environmental Risk Assessment, Osaka Metropolitan University Graduate School of Medicine, Osaka 554-8585, Japan.
Anna KakehashiDepartment of Molecular Pathology, Osaka Metropolitan University Graduate School of Medicine, Osaka 554-8585, Japan.ORCID 0000-0003-1149-1450
Ikue NouraDepartment of Molecular Pathology, Osaka Metropolitan University Graduate School of Medicine, Osaka 554-8585, Japan.
Xiaoli XieDepartment of Toxicology, School of Public Health, Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research), Guangzhou 510515, China.
Hideki WanibuchiDepartment of Environmental Risk Assessment, Osaka Metropolitan University Graduate School of Medicine, Osaka 554-8585, Japan.ORCID 0000-0001-9362-4290

Funding

Food Safety Commission, Cabinet Office, Government of Japan JPCAFSC20212102Health and Labour Sciences Research Grants from the Ministry of Health, Labour and Welfare of Japan 22KD1003Health and Labour Sciences Research Grants from the Ministry of Health, Labour and Welfare of Japan 24KD1002Japan Society for the Promotion of Science 23K09652
6 · The paper itself

Abstract

The urinary bladder is a primary target organ for environmental toxicants such as arsenic. The objects of this study were two-fold. First, we constructed a novel 3D urinary bladder mucosa model (3D-UBMM) composed of an overlying epithelium and a supporting subepithelial layer. Primary human bladder urothelial and fibroblast cells were immortalized by introducing the human CDK4

Indexed as

3D urinary bladder mucosa modelarsenictoxicity assessmenturothelial cell markerγ-H2AX

Identifiers

PMID41150527
PMCPMC12568184

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.