Evidence map›Paper›PMID 41150421›Full record

ArticleVaccines2025

Active and Passive Immunization of Pan-Fungal Vaccine NXT-2 Reduces Morbidity and Mortality in an Immunosuppressed Murine Model of

Kwadwo O Oworae, Emily Rayens, Taylor I Chapman, Daniel A Wychrij, Lizabeth Buzzelli, Whitney Rabacal, Karen A Norris

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kwadwo O OworaeCenter for Vaccines and Immunology, University of Georgia, Athens, GA 30602, USA.ORCID 0000-0002-6701-9465
Emily RayensCenter for Vaccines and Immunology, University of Georgia, Athens, GA 30602, USA.
Taylor I ChapmanCenter for Vaccines and Immunology, University of Georgia, Athens, GA 30602, USA.ORCID 0000-0001-8288-8848
Daniel A WychrijCenter for Vaccines and Immunology, University of Georgia, Athens, GA 30602, USA.ORCID 0000-0001-5702-9662
Lizabeth BuzzelliCenter for Vaccines and Immunology, University of Georgia, Athens, GA 30602, USA.
Whitney RabacalCenter for Vaccines and Immunology, University of Georgia, Athens, GA 30602, USA.
Karen A NorrisCenter for Vaccines and Immunology, University of Georgia, Athens, GA 30602, USA.

Funding

Prevention and Treatment of Pneumocystis PneumoniaR01AI148365 · NIAID · UNIVERSITY OF GEORGIA · PI NORRIS, KAREN A · 2020 to 2024
$3.7M
Georgia Research Alliance Charles H. Wheatley EndowmentNIAID NIH HHS R01 AI148365NIH grant 1R01AI148365 (K.A.N)University of Georgia Research Foundation KAN
6 · The paper itself

Abstract

background

methodsIn this study, we investigated the efficacy of NXT-2 immunization against systemic

resultsActive immunization afforded significant improvement in survival and reduced morbidity in neutropenic mice challenged intravenously with

conclusionsThese findings show that immunization with NXT-2 improves survival in

Indexed as

Candida aurisimmunosuppressioninvasive candidiasisNXT-2pan-fungal vaccinepassive transfer

Identifiers

PMID41150421
PMCPMC12567899

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.