ArticleVaccines2025
Preclinical Immunogenicity Evaluation of a DTacP-sIPV/Hib Combination Vaccine in Rodent Models Under Varying Formulations and Immunization Schedules.
Article in Vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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27 authors.
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Abstract
backgroundCombination vaccines protecting against diphtheria, tetanus, pertussis, poliomyelitis, and Haemophilus influenzae type b reduce injection burden and improve compliance. While widely used globally, no domestically produced pentavalent vaccine is currently licensed in China. Recent updates to China's immunization schedule-including earlier initiation and an added booster for pertussis-highlight the need for compatible combination vaccines. This study evaluated the immunogenicity and feasibility of a novel DTacP-sIPV/Hib candidate vaccine in preclinical models.
methodsThe vaccine was assessed in NIH mice and Wistar rats. Two Hib dosages were tested in mice alongside a DTacP-wIPV/Hib vaccine (Pentaxim
resultsThe candidate vaccine elicited robust immune responses in both models. In mice, after three doses, the high-dose Hib group achieved >90% seroconversion for pertactin antigen, whereas the low-dose group reached 100% for all antigens. In rats, antibody responses after three doses were comparable to those induced by Pentaxim
conclusionThe candidate DTacP-sIPV/Hib vaccine showed robust immunogenicity and flexibility across schedules and administration methods. A formulation including DT 12.5 Lf, TT 3.5 Lf, PT 25 μg, FHA 25 μg, PRN 8 μg, PRP 10 μg, and sIPV I/II/III at 30/32/45 DU is proposed for further development.
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