Evidence map›Paper›PMID 41150379›Full record

ArticleeLife2025

Changes in neural progenitor lineage composition during astrocytic differentiation of human iPSCs.

Zongze Li, Lucia Fernandez Cardo, Michal Rokicki, Jimena Monzón-Sandoval, Viola Volpato, Frank Wessely, Caleb Webber, Meng Li

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zongze LiDementia Research Institute, School of Medicine, Cardiff University, Cardiff, United Kingdom.
Lucia Fernandez CardoDementia Research Institute, School of Medicine, Cardiff University, Cardiff, United Kingdom.ORCID https://orcid.org/0000-0002-5407-8175
Michal RokickiDementia Research Institute, School of Medicine, Cardiff University, Cardiff, United Kingdom.
Jimena Monzón-SandovalDementia Research Institute, School of Medicine, Cardiff University, Cardiff, United Kingdom.
Viola VolpatoDementia Research Institute, School of Medicine, Cardiff University, Cardiff, United Kingdom.
Frank WesselyDementia Research Institute, School of Medicine, Cardiff University, Cardiff, United Kingdom.
Caleb WebberDementia Research Institute, School of Medicine, Cardiff University, Cardiff, United Kingdom.
Meng LiNeuroscience and Mental Health Innovation Institute, School of Medicine, Cardiff University, Cardiff, United Kingdom.ORCID https://orcid.org/0000-0002-4803-4643

Funding

UK Dementia Research Institute DRI-TRA2021-02UK Dementia Research Institute MC_PC_17112UK Dementia Research Institute PhD studentship
6 · The paper itself

Abstract

The regional specificity of stem cell-derived astrocytes is believed to be an important prerequisite for their application in disease modelling and cell-based therapies. Due to the lack of subtype-defining markers for astrocytes in different regions of the brain, the regional identity of in vitro-derived astrocytes is often declared by the dominant positional characteristics of their antecedent neural progenitors, patterned to a fate of interest, with the assumption that the positional trait is preserved by the derived astrocytes via linear descent. Using a human induced pluripotent stem cell line designed for tracing derivatives of LMX1A

Indexed as

AstrocytesCell DifferentiationCell LineageInduced Pluripotent Stem CellsNeural Stem CellsCell LineHumansLIM-Homeodomain ProteinsTranscription FactorsLIM-Homeodomain ProteinsLMX1A protein, humanTranscription Factorsastrocytedevelopmental biologyhumanlineage tracingmidbrainneural progenitorpatterningpluripotent stem cellregenerative medicinestem cells

Identifiers

PMID41150379
PMCPMC12563561

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.