Evidence map›Paper›PMID 41150374›Full record

ReviewTropical medicine and infectious disease2025

Impact of El Nino Southern Oscillation and Climate Change on Infectious Diseases with Ophthalmic Manifestations.

Crystal Huang, Caleb M Yeh, Claire Ufongene, Tolulope Fashina, R V Paul Chan, Jessica G Shantha, Steven Yeh, Jean-Claude Mwanza

Abstract readReview
In one paragraph

Review in Tropical medicine and infectious disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Crystal HuangTruhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE 68105, USA.
Caleb M YehTruhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE 68105, USA.
Claire UfongeneDepartment of Ophthalmology and Visual Sciences, University of Illinois Chicago, Chicago, IL 60612, USA.
Tolulope FashinaTruhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE 68105, USA.
R V Paul ChanDepartment of Ophthalmology and Visual Sciences, University of Illinois Chicago, Chicago, IL 60612, USA.
Jessica G ShanthaF.I. Proctor Foundation, Department of Ophthalmology, University of California San Francisco, San Francisco, CA 94107, USA.
Steven YehTruhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE 68105, USA.
Jean-Claude MwanzaDepartment of Ophthalmology, University of North Carolina, Chapel Hill, NC 27514, USA.

Funding

Pathogenesis of Uveitis in Ebola Virus Disease SurvivorsR01EY029594 · NEI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI YEH, STEVEN · 2019 to 2023
$2.9M
NEI NIH HHS R01 EY029594NIH HHS 1R01EY029594-24
6 · The paper itself

Abstract

Climate change and the El Niño Southern Oscillation (ENSO) events have been increasingly linked to infectious disease outbreaks. While growing evidence has connected climate variability with systemic illnesses, the ocular implications remain underexplored. This study aimed to assess the relationships between ENSO-driven climate events and infectious diseases with ophthalmic consequences. A narrative review of 255 articles was conducted, focusing on infectious diseases influenced by ENSO and their associated ocular findings. 39 articles met criteria for full review, covering diseases such as dengue, zika, chikungunya, malaria, leishmaniasis, leptospirosis, and Rift Valley fever. Warmer temperatures, increased rainfall, and humidity associated with ENSO events were found to enhance vector activity and disease transmission. Ocular complications included uveitis, retinopathy, and optic neuropathy, but the specific disease findings varied by infectious disease syndrome. The climactic variable changes in response to ENSO events differed across diseases and regions and were influenced by geography, local infrastructure, and socioeconomic factors. ENSO event-related climate shifts significantly impact the spread of infectious diseases with ocular symptoms. These findings highlight the need for region-specific surveillance and predictive models that may provide insight related to the risk of ophthalmic disease during ENSO events. Further research is needed to clarify long-term ENSO effects and develop integrated strategies for systemic and eye disease detection, prevention, and management.

Indexed as

chikungunyaclimate changedengueEl Nino Southern Oscillationemerging infectious diseasesmalariaophthalmology

Identifiers

PMID41150374
PMCPMC12567761

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.